NAA11: N-alpha-acetyltransferase 11, NatA catalytic subunit
Gene encoding the catalytic subunit of the N-terminal acetyltransferase A (NatA) complex, involved in co-translational protein acetylation.
Gene Information Card
| Symbol | NAA11 |
|---|---|
| Full Name | N-alpha-acetyltransferase 11, NatA catalytic subunit |
| Gene Type | protein-coding |
| Chromosomal Location | 4q21.23 |
| NCBI Gene ID | 84779 ncbi.nlm.nih.gov/gene/84779 |
| Ensembl ID | ENSG00000138614 |
| UniProt ID | Q9BSU3 |
| OMIM ID | 612770 |
| HGNC ID | 30437 |
| Aliases | ARD1B, hARD2, NAA11, NATD |
Description
NAA11 encodes the catalytic subunit of the N-terminal acetyltransferase A (NatA) complex, which catalyzes the co-translational acetylation of the alpha-amino group of nascent polypeptides after the initiator methionine is removed. This modification is critical for protein stability, localization, and function. NAA11 is broadly expressed and has been implicated in cellular proliferation and differentiation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Altered NatA activity may affect acetylation of oncoproteins and tumor suppressors, influencing cell cycle and apoptosis. | COSMIC; literature review |
| Developmental disorders | Mutations in NAA11 may disrupt NatA function, leading to impaired protein acetylation and developmental abnormalities. | OMIM; ClinVar |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.2 | Low |
| Liver | 6.1 | Low |
| Kidney | 5.4 | Low |
| Heart | 4.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 10.3 | High expression in embryonic kidney cells |
| HeLa | 7.1 | Moderate expression in cervical cancer cells |
| K562 | 6.5 | Moderate expression in leukemia cells |
| A549 | 5.9 | Low expression in lung cancer cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | missense | <0.01% | Likely loss of start codon, affecting translation initiation |
| c.205C>T (p.Arg69Trp) | missense | <0.01% | Unknown functional effect; rare variant |
| c.340G>A (p.Glu114Lys) | missense | <0.01% | Unknown functional effect; rare variant |
Mutation functional classification
Loss of Function (LOF)
Loss-of-function mutations in NAA11 are predicted to reduce NatA catalytic activity, impairing N-terminal acetylation of substrates.
Gain of Function (GOF)
No gain-of-function mutations have been reported for NAA11.
Dominant Negative (DN)
No dominant-negative mutations have been described for NAA11.
View complete mutation data：
Gene Ontology (GO)
| • peptide alpha-N-acetyltransferase activity (GO:0004596) | • cytoplasm (GO:0005737) |
| • cytosol (GO:0005829) | • transferase activity (GO:0016740) |
| • L-ascorbic acid binding (GO:0031418) | • intracellular membrane-bounded organelle (GO:0043231) |
| • peptidyl-lysine acetylation (GO:0061134) |
Pathways
• N-terminal acetylation of proteins (NatA complex)
• Co-translational protein modification
Protein Summary
NAA11 is the catalytic subunit of the NatA complex, which acetylates the N-terminus of proteins after initiator methionine removal. The protein contains an acetyltransferase domain and is essential for proper protein folding, stability, and cellular function. NAA11 is widely expressed and its dysregulation is linked to cancer and developmental disorders.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| NAA11 Knockout HEK293 Cell Line | EDJ-KQ10196 | Human | 84779 | Details Get a Quote |
| NAA11 Knockout HeLa Cell Line | EDJ-KQ57661 | Human | 84779 | Details Get a Quote |
| NAA11 Knockout A-549 Cell Line | EDJ-KQ66159 | Human | 84779 | Details Get a Quote |
| NAA11 Knockout HCT 116 Cell Line | EDJ-KQ74585 | Human | 84779 | Details Get a Quote |
