MYO18B
Myosin XVIIIB: A Tumor Suppressor Gene in Lung and Ovarian Cancer
Gene Information Card
| Symbol | MYO18B |
|---|---|
| Full Name | myosin XVIIIB |
| Gene Type | protein coding |
| Chromosomal Location | 22q12.1 |
| NCBI Gene ID | 84700 ncbi.nlm.nih.gov/gene/84700 |
| Ensembl ID | ENSG00000100241 |
| UniProt ID | Q8IY21 |
| OMIM ID | 607295 |
| HGNC ID | 18150 |
| Aliases | KIAA1460, MYO18Bbeta, MYO18Balpha |
Description
MYO18B encodes a member of the myosin superfamily, specifically an unconventional myosin involved in cytoskeletal organization, cell adhesion, and intracellular transport. It functions as a tumor suppressor, with loss of expression or inactivating mutations frequently observed in lung cancer and ovarian cancer. The protein contains an N-terminal PDZ domain and a myosin head domain, and it localizes to actin filaments.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Lung cancer | Loss of expression due to promoter methylation or deletion; reduced tumor suppression | PMID: 14678951, COSMIC |
| Ovarian cancer | Inactivating mutations and copy number loss impair cell adhesion and promote metastasis | PMID: 21573161, ClinVar |
| Colorectal cancer | Reduced MYO18B expression correlates with poor prognosis | PMID: 23792584 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 5.2 nTPM | Low |
| Ovary | 3.8 nTPM | Low |
| Testis | 1.1 nTPM | Not detected |
| Brain | 0.5 nTPM | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 (lung cancer) | 2.1 nTPM | Reduced expression vs normal lung |
| OVCAR-3 (ovarian cancer) | 1.5 nTPM | Low expression |
| HEK293 | 4.0 nTPM | Moderate expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412*) | Nonsense | <1% in lung cancer | Loss of function |
| c.567_568del (p.Glu189fs) | Frameshift | <1% in ovarian cancer | Loss of function |
| c.2345G>A (p.Arg782Gln) | Missense | <1% in colorectal cancer | Unknown significance |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations lead to truncated protein and loss of tumor suppressor activity.
Gain of Function (GOF)
No evidence of gain-of-function mutations.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • actin binding | • ATP binding |
| • microtubule motor activity | • cytoskeleton |
| • cell adhesion |
Pathways
• Actin cytoskeleton regulation
• Tumor suppressor pathways
Protein Summary
MYO18B is a 2,470-amino acid unconventional myosin with an N-terminal PDZ domain, a myosin motor domain, and a coiled-coil tail. It binds actin and ATP, localizes to stress fibers, and regulates cell shape, adhesion, and migration. Loss of MYO18B expression is a hallmark of several cancers, particularly lung and ovarian.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MYO18B Knockout HEK293 Cell Line | EDJ-KQ2003 | Human | 84700 | Details Get a Quote |
| MYO18B Knockout HeLa Cell Line | EDJ-KQ57653 | Human | 84700 | Details Get a Quote |
| MYO18B Knockout A-549 Cell Line | EDJ-KQ66151 | Human | 84700 | Details Get a Quote |
| MYO18B Knockout HCT 116 Cell Line | EDJ-KQ74578 | Human | 84700 | Details Get a Quote |
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