MYCT1: MYC Target 1, a Putative Tumor Suppressor Gene
Comprehensive genomic and functional analysis of MYCT1, a MYC-regulated gene implicated in cancer and cellular differentiation.
Gene Information Card
| Symbol | MYCT1 |
|---|---|
| Full Name | MYC Target 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 6q25.3 |
| NCBI Gene ID | 80177 ncbi.nlm.nih.gov/gene/80177 |
| Ensembl ID | ENSG00000120217 |
| UniProt ID | Q8N2Z9 |
| OMIM ID | 616728 |
| HGNC ID | 24828 |
| Aliases | MTLC, MYC target in laryngeal cancer |
Description
MYCT1 (MYC Target 1) is a protein-coding gene located on chromosome 6q25.3. It was initially identified as a direct transcriptional target of the MYC oncogene and is thought to function as a tumor suppressor. The gene encodes a nuclear protein involved in cell cycle regulation, apoptosis, and differentiation. Downregulation of MYCT1 has been observed in several cancers, including laryngeal squamous cell carcinoma, gastric cancer, and hepatocellular carcinoma, suggesting a role in tumorigenesis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Laryngeal Squamous Cell Carcinoma | Downregulation of MYCT1 by promoter methylation or MYC dysregulation leads to loss of growth suppression. | PMID: 15674326 |
| Gastric Cancer | Reduced MYCT1 expression correlates with poor prognosis and increased proliferation. | PMID: 23443108 |
| Hepatocellular Carcinoma | MYCT1 acts as a tumor suppressor; its loss promotes cell migration and invasion. | PMID: 27323849 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 5.2 | Low |
| Liver | 3.8 | Low |
| Kidney | 4.1 | Low |
| Testis | 6.7 | Medium |
| Thyroid | 5.9 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 4.5 | Cervical cancer cell line |
| A549 | 3.2 | Lung cancer cell line |
| HepG2 | 2.8 | Hepatocellular carcinoma cell line |
| MCF7 | 5.0 | Breast cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.1% | Unknown significance |
| c.214C>T | Nonsense | <0.1% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations (e.g., c.214C>T) are predicted to cause premature truncation and loss of protein function.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • nucleus | • protein binding |
| • negative regulation of cell population proliferation | • apoptotic process |
| • transcription cis-regulatory region binding |
Pathways
• MYC transcriptional regulation
• p53 signaling pathway (indirect)
Protein Summary
The MYCT1 protein is a 224-amino-acid nuclear protein with a molecular weight of approximately 25 kDa. It contains a putative nuclear localization signal and is involved in transcriptional regulation. MYCT1 is thought to mediate some of the tumor-suppressive effects of MYC by promoting apoptosis and inhibiting cell cycle progression. Its expression is frequently silenced by promoter hypermethylation in cancer.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MYCT1 Knockout HEK293 Cell Line | EDJ-KQ9472 | Human | 80177 | Details Get a Quote |
| MYCT1 Knockout HeLa Cell Line | EDJ-KQ57304 | Human | 80177 | Details Get a Quote |
| MYCT1 Knockout A-549 Cell Line | EDJ-KQ65812 | Human | 80177 | Details Get a Quote |
| MYCT1 Knockout HCT 116 Cell Line | EDJ-KQ74235 | Human | 80177 | Details Get a Quote |
