MYCBP: MYC Binding Protein Gene
A key modulator of MYC transcriptional activity and cell proliferation
Gene Information Card
| Symbol | MYCBP |
|---|---|
| Full Name | MYC binding protein |
| Gene Type | protein-coding |
| Chromosomal Location | 1p34.2 |
| NCBI Gene ID | 26292 ncbi.nlm.nih.gov/gene/26292 |
| Ensembl ID | ENSG00000116183 |
| UniProt ID | Q99417 |
| OMIM ID | 606544 |
| HGNC ID | 7552 |
| Aliases | AMY-1, MYCBP1, MGC111099 |
Description
MYCBP (MYC binding protein) encodes a protein that binds to the N-terminal region of the MYC oncoprotein, enhancing MYC-mediated transcriptional activation. It is involved in cell cycle progression, proliferation, and apoptosis. MYCBP is widely expressed and has been implicated in various cancers and developmental processes.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | MYCBP overexpression enhances MYC activity, promoting cell proliferation | PMID: 12354779 |
| Colorectal cancer | MYCBP amplification correlates with poor prognosis | PMID: 15616553 |
| Hepatocellular carcinoma | MYCBP upregulation linked to MYC-driven tumorigenesis | PMID: 18332868 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Lymph node | 8.3 | Medium |
| Brain | 6.1 | Low |
| Liver | 4.8 | Low |
| Heart | 3.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.2 | High expression |
| HeLa | 10.7 | Moderate expression |
| MCF7 | 9.1 | Moderate expression |
| HepG2 | 7.4 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.01% | Unknown |
| c.214C>T | missense | <0.01% | Unknown |
| c.367G>A | missense | <0.01% | Unknown |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in MYCBP.
Gain of Function (GOF)
Overexpression or amplification of MYCBP is associated with enhanced MYC activity in cancers.
Dominant Negative (DN)
No dominant-negative mutations described for MYCBP.
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) | • nucleus (GO:0005634) |
| • cytoplasm (GO:0005737) | • positive regulation of transcription by RNA polymerase II (GO:0045944) |
| • cell proliferation (GO:0008283) |
Pathways
• MYC pathway
• Transcriptional regulation by MYC
• Cell cycle
Protein Summary
MYCBP is a 156-amino acid protein that contains a coiled-coil domain and interacts with the N-terminal transactivation domain of MYC. It enhances MYC's ability to activate transcription of target genes involved in cell growth and division. MYCBP also interacts with other proteins such as AMY-1 and may have roles in spermatogenesis and neuronal function.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MYCBP2 Knockout HEK293 Cell Line | EDJ-KQ7815 | Human | 23077 | Details Get a Quote |
| MYCBPAP Knockout HEK293 Cell Line | EDJ-KQ9970 | Human | 84073 | Details Get a Quote |
| MYCBP2 Knockout HCT 116 Cell Line | EDJ-KQ32016 | Human | 23077 | Details Get a Quote |
| MYCBP2 Knockout A-549 Cell Line | EDJ-KQ33342 | Human | 23077 | Details Get a Quote |
| MYCBP2 Knockout HeLa Cell Line | EDJ-KQ33343 | Human | 23077 | Details Get a Quote |
| MYCBPAP Knockout A-549 Cell Line | EDJ-KQ36903 | Human | 84073 | Details Get a Quote |
| MYCBP Knockout HEK293 Cell Line | EDJ-KQ51178 | Human | 26292 | Details Get a Quote |
| MYCBP Knockout HeLa Cell Line | EDJ-KQ55927 | Human | 26292 | Details Get a Quote |
| MYCBPAP Knockout HeLa Cell Line | EDJ-KQ57528 | Human | 84073 | Details Get a Quote |
| MYCBP Knockout A-549 Cell Line | EDJ-KQ64415 | Human | 26292 | Details Get a Quote |
| MYCBP Knockout HCT 116 Cell Line | EDJ-KQ72869 | Human | 26292 | Details Get a Quote |
| MYCBPAP Knockout HCT 116 Cell Line | EDJ-KQ74450 | Human | 84073 | Details Get a Quote |
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