MTARC2: Mitochondrial Amidoxime Reducing Component 2
A molybdenum cofactor-containing enzyme involved in drug metabolism and nitric oxide synthesis.
Gene Information Card
| Symbol | MTARC2 |
|---|---|
| Full Name | Mitochondrial Amidoxime Reducing Component 2 |
| Gene Type | Protein coding |
| Chromosomal Location | 1q41 |
| NCBI Gene ID | 54996 ncbi.nlm.nih.gov/gene/54996 |
| Ensembl ID | ENSG00000143178 |
| UniProt ID | Q5VT66 |
| OMIM ID | 615126 |
| HGNC ID | 28795 |
| Aliases | mARC2, MOSC2, MARC2 |
Description
MTARC2 (Mitochondrial Amidoxime Reducing Component 2) encodes a molybdenum cofactor-containing enzyme localized to the mitochondrial outer membrane. It functions as a component of the mitochondrial amidoxime reducing complex (mARC), which reduces N-hydroxylated compounds such as amidoximes and sulfoximes, playing a role in drug metabolism and the regulation of nitric oxide synthesis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association | Not established | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Kidney | 8.3 | Medium |
| Heart | 3.1 | Low |
| Brain | 1.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 15.0 | Hepatocellular carcinoma cell line |
| HEK293 | 7.2 | Embryonic kidney cells |
| K562 | 2.1 | Leukemia cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported pathogenic variants | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • catalytic activity (GO:0003824) | • iron ion binding (GO:0005506) |
| • oxidoreductase activity (GO:0016491) | • molybdenum ion binding (GO:0030151) |
| • mitochondrial outer membrane (GO:0005741) |
Pathways
• Amidoxime reduction (mARC complex)
• Nitric oxide biosynthesis
Protein Summary
MTARC2 encodes a 337-amino acid protein (UniProt Q5VT66) that contains a MOSC (Molybdenum Cofactor Sulfurase) domain. It forms a complex with cytochrome b5 and NADH cytochrome b5 reductase to catalyze the reduction of N-hydroxylated substrates. The protein is highly expressed in liver and kidney, consistent with its role in detoxification and metabolism.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MTARC2 Knockout HEK293 Cell Line | EDJ-KQ14328 | Human | 54996 | Details Get a Quote |
| MTARC2 Knockout A-549 Cell Line | EDJ-KQ43190 | Human | 54996 | Details Get a Quote |
| MTARC2 Knockout HCT 116 Cell Line | EDJ-KQ44428 | Human | 54996 | Details Get a Quote |
| MTARC2 Knockout HeLa Cell Line | EDJ-KQ44429 | Human | 54996 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
