MTA2: Metastasis-Associated Protein 2 in Cancer and Chromatin Remodeling
Comprehensive gene card for MTA2, a core component of the NuRD complex involved in transcriptional repression, cell cycle control, and tumor metastasis.
Gene Information Card
| Symbol | MTA2 |
|---|---|
| Full Name | Metastasis Associated 1 Family Member 2 |
| Gene Type | Protein coding |
| Chromosomal Location | 11q12.3 |
| NCBI Gene ID | 9219 ncbi.nlm.nih.gov/gene/9219 |
| Ensembl ID | ENSG00000149480 |
| UniProt ID | O94776 |
| OMIM ID | 603947 |
| HGNC ID | 7411 |
| Aliases | MTA1L1, PID, MTA2 |
Description
MTA2 (Metastasis Associated 1 Family Member 2) encodes a component of the nucleosome remodeling and deacetylase (NuRD) complex. This protein functions in chromatin remodeling, histone deacetylation, and transcriptional repression. MTA2 is involved in cell cycle regulation, DNA damage response, and has been implicated in cancer metastasis and progression. It is widely expressed in various tissues and is associated with multiple malignancies.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Overexpression of MTA2 promotes metastasis by repressing E-cadherin and enhancing cell migration and invasion. | PMID: 15694340; NCBI Gene |
| Gastric cancer | MTA2 upregulation correlates with poor prognosis and promotes epithelial-mesenchymal transition (EMT). | PMID: 23327982; NCBI Gene |
| Hepatocellular carcinoma | MTA2 enhances tumor growth and metastasis via NuRD complex-mediated transcriptional repression. | PMID: 21725308; NCBI Gene |
| Non-small cell lung cancer | MTA2 overexpression is associated with advanced stage and lymph node metastasis. | PMID: 22430205; NCBI Gene |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 28.5 | High |
| Brain | 15.2 | Medium |
| Lung | 12.8 | Medium |
| Liver | 10.1 | Medium |
| Breast | 8.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 22.3 | Cervical cancer cell line |
| MCF7 | 18.7 | Breast cancer cell line |
| A549 | 15.9 | Lung cancer cell line |
| HepG2 | 14.2 | Liver cancer cell line |
| K562 | 11.5 | Leukemia cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1015C>T (p.Arg339Trp) | Missense | 0.02% (COSMIC) | Unknown functional impact; located in the SANT domain |
| c.1246G>A (p.Glu416Lys) | Missense | 0.01% (COSMIC) | Potential alteration of protein-protein interactions |
| c.1489_1490insA (p.Thr497Asnfs*5) | Frameshift | 0.005% (COSMIC) | Predicted loss of function due to premature truncation |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations that truncate the protein, disrupting NuRD complex assembly and chromatin remodeling activity.
Gain of Function (GOF)
Not well characterized; some missense mutations may enhance stability or interaction with partners, but evidence is limited.
Dominant Negative (DN)
Mutations in the SANT domain may produce a protein that competes with wild-type MTA2, impairing NuRD function.
View complete mutation data：
Gene Ontology (GO)
Pathways
• NuRD complex pathway (Reactome: R-HSA-212300)
• Chromatin modifying enzymes (KEGG: hsa05200)
• Transcriptional misregulation in cancer (KEGG: hsa05202)
Protein Summary
MTA2 is a 668-amino acid protein that contains a SANT domain, a GATA-like zinc finger, and a leucine zipper motif. It is a core component of the NuRD complex, which couples ATP-dependent chromatin remodeling with histone deacetylase activity. MTA2 interacts with HDAC1/2, CHD3/4, and other NuRD subunits to repress transcription of target genes involved in cell adhesion, proliferation, and metastasis. Post-translational modifications include phosphorylation and acetylation, which modulate its stability and activity.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MTA2 Knockout HEK293 Cell Line | EDJ-KQ6507 | Human | 9219 | Details Get a Quote |
| MTA2 Knockout HCT 116 Cell Line | EDJ-KQ29304 | Human | 9219 | Details Get a Quote |
| MTA2 Knockout A-549 Cell Line | EDJ-KQ30650 | Human | 9219 | Details Get a Quote |
| MTA2 Knockout HeLa Cell Line | EDJ-KQ30652 | Human | 9219 | Details Get a Quote |
