MST1R (Macrophage Stimulating 1 Receptor)
A receptor tyrosine kinase involved in macrophage activation, cell migration, and cancer progression.
Gene Information Card
| Symbol | MST1R |
|---|---|
| Full Name | Macrophage Stimulating 1 Receptor |
| Gene Type | protein-coding |
| Chromosomal Location | 3p21.31 |
| NCBI Gene ID | 4486 ncbi.nlm.nih.gov/gene/4486 |
| Ensembl ID | ENSG00000164078 |
| UniProt ID | Q04912 |
| OMIM ID | 600168 |
| HGNC ID | 7382 |
| Aliases | RON, CD136, PTK8 |
Description
MST1R (Macrophage Stimulating 1 Receptor) encodes a receptor tyrosine kinase (RTK) of the MET family. It is activated by its ligand, macrophage-stimulating protein (MSP, encoded by MST1). MST1R regulates cell proliferation, migration, and survival, particularly in macrophages and epithelial cells. Aberrant expression and mutations are implicated in various cancers and inflammatory conditions.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (e.g., breast, lung, colorectal) | Overexpression or activating mutations promote cell invasion and metastasis | COSMIC, ClinVar |
| Inflammatory bowel disease | Dysregulated macrophage activation via MSP-MST1R signaling | OMIM, NCBI |
| Obesity-associated insulin resistance | MST1R signaling in adipose tissue macrophages | NCBI, PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 8.5 | Medium |
| Lung | 6.2 | Medium |
| Kidney | 4.1 | Low |
| Breast | 3.8 | Low |
| Colon | 2.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| THP-1 (monocyte) | 12.3 | High expression in monocytic lineage |
| A549 (lung cancer) | 7.8 | Moderate expression |
| MCF7 (breast cancer) | 5.1 | Low expression |
| HepG2 (liver cancer) | 4.6 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.3070C>T (p.Arg1024Cys) | Missense | 0.2% (COSMIC) | Potential gain-of-function in cancer |
| c.3026G>A (p.Arg1009Gln) | Missense | 0.1% (COSMIC) | Unknown significance |
| c.1-?_*_?del | Deletion | Rare | Loss-of-function reported in some cancers |
Mutation functional classification
Loss of Function (LOF)
Rare deletions or truncating mutations reduce receptor signaling, potentially impairing macrophage function.
Gain of Function (GOF)
Missense mutations (e.g., R1024C) may enhance kinase activity, promoting oncogenic signaling.
Dominant Negative (DN)
Not well characterized; some splice variants may act as dominant negatives.
View complete mutation data：
Gene Ontology (GO)
Pathways
• MSP/MST1R signaling pathway
• PI3K-Akt signaling pathway
• MAPK signaling pathway
• RAS signaling
Protein Summary
MST1R (RON) is a 180 kDa transmembrane receptor tyrosine kinase. It consists of an extracellular alpha chain and a transmembrane beta chain with intracellular kinase domain. Binding of MSP induces dimerization and autophosphorylation, activating downstream pathways such as PI3K/Akt and MAPK. Overexpression and mutations are linked to tumor progression and metastasis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MST1R Knockout HEK293 Cell Line | EDJ-KQ1614 | Human | 4486 | Details Get a Quote |
| MST1R Knockout A-549 Cell Line | EDJ-KQ21298 | Human | 4486 | Details Get a Quote |
| MST1R Knockout HCT 116 Cell Line | EDJ-KQ21299 | Human | 4486 | Details Get a Quote |
| MST1R Knockout HeLa Cell Line | EDJ-KQ21300 | Human | 4486 | Details Get a Quote |
