MSMP (Microseminoprotein, Prostate Associated)
Gene encoding prostatic secretory protein of 94 amino acids (PSP94), also known as beta-microseminoprotein, involved in prostate biology and potential tumor suppression.
Gene Information Card
| Symbol | MSMP |
|---|---|
| Full Name | Microseminoprotein, Prostate Associated |
| Gene Type | Protein coding |
| Chromosomal Location | 9p13.3 |
| NCBI Gene ID | 7157 ncbi.nlm.nih.gov/gene/7157 |
| Ensembl ID | ENSG00000107262 |
| UniProt ID | P08118 |
| OMIM ID | 176810 |
| HGNC ID | 7382 |
| Aliases | PSP94, IGBF, MSP, beta-microseminoprotein, prostatic secretory protein 94 |
Description
MSMP encodes beta-microseminoprotein (also known as PSP94), a small cysteine-rich secretory protein predominantly produced by the prostate gland. It is secreted into seminal plasma and is thought to play roles in sperm motility, immunomodulation, and potential tumor suppression. Reduced expression is observed in prostate cancer, suggesting a possible tumor suppressor function.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Prostate cancer | Reduced MSMP expression correlates with tumor progression and poor prognosis; may act as a tumor suppressor via modulation of cell growth and apoptosis. | PMID: 10652318, PMID: 15604205 |
| Prostatic hyperplasia | Altered expression levels observed in benign prostatic hyperplasia tissues compared to normal prostate. | PMID: 11304735 |
| Infertility | Beta-microseminoprotein levels in seminal plasma are associated with sperm quality and fertility status. | PMID: 17662314 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Prostate | 1056.2 | High |
| Trachea | 12.3 | Low |
| Lung | 8.7 | Low |
| Salivary gland | 6.1 | Low |
| Testis | 4.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| PC-3 (prostate cancer) | 0.2 | Very low expression |
| LNCaP (prostate cancer) | 0.1 | Very low expression |
| DU145 (prostate cancer) | 0.3 | Very low expression |
| RWPE-1 (normal prostate) | 45.6 | Moderate expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | <0.01% | Likely loss of start codon; predicted to abolish protein translation |
| c.214C>T (p.Arg72Cys) | Missense | <0.01% | Rare variant; functional impact unknown |
| c.328G>A (p.Gly110Ser) | Missense | <0.01% | Rare variant; functional impact unknown |
Mutation functional classification
Loss of Function (LOF)
Loss-of-function mutations (e.g., start codon loss) are predicted to reduce or eliminate PSP94 protein, potentially contributing to prostate cancer progression.
Gain of Function (GOF)
No gain-of-function mutations have been reported for MSMP.
Dominant Negative (DN)
No dominant-negative mutations have been described for MSMP.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Not assigned to any specific KEGG or Reactome pathway.
Protein Summary
Beta-microseminoprotein (PSP94) is a 94-amino acid secreted protein abundant in seminal plasma. It contains 10 cysteine residues forming five disulfide bonds, characteristic of the beta-microseminoprotein family. The protein is synthesized as a precursor with a 20-amino acid signal peptide. PSP94 has been implicated in modulation of sperm motility, immunosuppression in the female reproductive tract, and potential tumor suppression in the prostate. Its expression is markedly reduced in prostate cancer tissues, and it is considered a candidate biomarker for prostate cancer diagnosis and prognosis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MSMP Knockout HEK293 Cell Line | EDJ-KQ14322 | Human | 692094 | Details Get a Quote |
| MSMP Knockout HeLa Cell Line | EDJ-KQ60673 | Human | 692094 | Details Get a Quote |
| MSMP Knockout A-549 Cell Line | EDJ-KQ69147 | Human | 692094 | Details Get a Quote |
| MSMP Knockout HCT 116 Cell Line | EDJ-KQ77499 | Human | 692094 | Details Get a Quote |
