MS4A14: Membrane Spanning 4-Domains A14
A member of the MS4A family with potential roles in immune signaling and cancer
Gene Information Card
| Symbol | MS4A14 |
|---|---|
| Full Name | Membrane Spanning 4-Domains A14 |
| Gene Type | protein-coding |
| Chromosomal Location | 11q12.1 |
| NCBI Gene ID | 84689 ncbi.nlm.nih.gov/gene/84689 |
| Ensembl ID | ENSG00000166979 |
| UniProt ID | Q96JQ5 |
| OMIM ID | 606897 |
| HGNC ID | 14919 |
| Aliases | CD20-L4, MS4A7, 4SPAN4 |
Description
MS4A14 (Membrane Spanning 4-Domains A14) is a protein-coding gene belonging to the MS4A family, which includes CD20 (MS4A1) and other immune-related molecules. The encoded protein contains four transmembrane domains and is involved in signal transduction, particularly in B-cell and myeloid cell function. MS4A14 is located on chromosome 11q12.1 within a cluster of MS4A genes. Its expression is enriched in lymphoid tissues and certain cancers, suggesting a role in immune regulation and oncogenesis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Diffuse Large B-Cell Lymphoma | Altered expression may contribute to B-cell proliferation | NCBI Gene, OMIM |
| Chronic Lymphocytic Leukemia | Potential involvement in B-cell signaling dysregulation | NCBI Gene |
| Breast Cancer | Overexpression observed in some subtypes; possible oncogenic role | NCBI Gene, COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Spleen | 12.5 | Medium |
| Lymph Node | 10.2 | Medium |
| Bone Marrow | 8.1 | Low |
| Lung | 2.3 | Low |
| Breast | 1.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Raji (Burkitt lymphoma) | 15.0 | B-cell line |
| K-562 (leukemia) | 7.8 | Myeloid line |
| MCF7 (breast cancer) | 4.2 | Epithelial line |
| HEK293 (embryonic kidney) | 0.5 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.500C>T (p.Pro167Leu) | Missense | <0.1% | Unknown functional impact |
| c.742G>A (p.Val248Ile) | Missense | <0.1% | Reported in COSMIC; uncertain significance |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • plasma membrane (GO:0005886) | • integral component of membrane (GO:0016021) |
| • signal transduction (GO:0007165) | • cell proliferation (GO:0008283) |
Pathways
• ['B cell receptor signaling pathway'
• 'Reactome']
• ['CD20-like signaling'
• 'KEGG']
Protein Summary
The MS4A14 protein is a four-transmembrane domain protein localized to the plasma membrane. It shares structural homology with CD20 (MS4A1) and may function as a calcium channel or receptor component in immune cells. Its expression in lymphoid tissues and cancer cell lines suggests a role in B-cell activation and tumorigenesis, though precise molecular functions remain under investigation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MS4A14 Knockout HEK293 Cell Line | EDJ-KQ10162 | Human | 84689 | Details Get a Quote |
| MS4A14 Knockout HeLa Cell Line | EDJ-KQ57646 | Human | 84689 | Details Get a Quote |
| MS4A14 Knockout A-549 Cell Line | EDJ-KQ66144 | Human | 84689 | Details Get a Quote |
| MS4A14 Knockout HCT 116 Cell Line | EDJ-KQ74571 | Human | 84689 | Details Get a Quote |
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