MRGPRX4 Gene
MAS-related GPR family member X4
Gene Information Card
| Symbol | MRGPRX4 |
|---|---|
| Full Name | MAS related GPR family member X4 |
| Gene Type | protein-coding |
| Chromosomal Location | 11p15.1 |
| NCBI Gene ID | 117196 ncbi.nlm.nih.gov/gene/117196 |
| Ensembl ID | ENSG00000179833 |
| UniProt ID | Q96LB2 |
| OMIM ID | 607232 |
| HGNC ID | 17920 |
| Aliases | GPCR, MRGX4, SNSR4 |
Description
MRGPRX4 (MAS related GPR family member X4) is a G protein-coupled receptor (GPCR) that belongs to the MAS-related gene (MRG) family. It is primarily expressed in sensory neurons and functions as a receptor for bile acids, mediating itch and pain signals. MRGPRX4 is implicated in cholestatic pruritus and other itch-related conditions.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cholestatic pruritus | Activation by bile acids (e.g., deoxycholic acid) leads to itch signaling in sensory neurons | PMID: 30867591 |
| Chronic pruritus | Overexpression or hypersensitivity to bile acids contributes to chronic itch | PMID: 30867591 |
| Pain perception | Modulation of nociceptive pathways via G protein signaling | PMID: 30867591 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Skin | 0.0 | Not detected |
| Spinal cord | 0.0 | Not detected |
| Dorsal root ganglia | 0.0 | Not detected |
| Liver | 0.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.0 | Not expressed endogenously |
| SH-SY5Y | 0.0 | Not expressed endogenously |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | SNV | <0.01% | Unknown |
| c.100C>T | SNV | <0.01% | Unknown |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function variants reported.
Gain of Function (GOF)
No confirmed gain-of-function variants reported.
Dominant Negative (DN)
No confirmed dominant-negative variants reported.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity (GO:0004930) | • bile acid receptor activity (GO:0038180) |
| • plasma membrane (GO:0005886) | • signal transduction (GO:0007165) |
| • response to bile acid (GO:0038181) |
Pathways
• GPCR downstream signaling
• Bile acid signaling in sensory neurons
Protein Summary
MRGPRX4 is a 338-amino acid G protein-coupled receptor with seven transmembrane domains. It is activated by bile acids such as deoxycholic acid and lithocholic acid, leading to Gq/11-mediated calcium mobilization. The receptor is expressed in a subset of sensory neurons and is involved in itch and pain transmission. Its structure and signaling are targets for therapeutic intervention in pruritus.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MRGPRX4 Overexpression HEK293 Stable Cell Line | EDJ0039-G14 | Human | 117196 | Details Get a Quote |
| MRGPRX4 Knockout HEK293 Cell Line | EDJ-KQ7601 | Human | 117196 | Details Get a Quote |
| MRGPRX4 Knockout HeLa Cell Line | EDJ-KQ58010 | Human | 117196 | Details Get a Quote |
| MRGPRX4 Knockout A-549 Cell Line | EDJ-KQ66498 | Human | 117196 | Details Get a Quote |
| MRGPRX4 Knockout HCT 116 Cell Line | EDJ-KQ74917 | Human | 117196 | Details Get a Quote |
| MRGPRX4 Knockout HEK293T Cell Line | EDC90111 | Human | 117196 | Details Get a Quote |
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