MRC2 Gene - Mannose Receptor C Type 2 | Function, Mutations & Diseases

MRC2 encodes the mannose receptor C type 2, also known as uPARAP (urokinase plasminogen activator receptor-associated protein) or Endo180. This transmembrane glycoprotein is a member of the mannose receptor family and functions as an endocytic receptor for collagen, playing a critical role in extracellular matrix remodeling, cell migration, and tissue homeostasis. It is expressed on fibroblasts, macrophages, and certain epithelial cells, and its dysregulation is implicated in fibrosis, cancer invasion, and metastasis.

Tissue Expression

Cell Line Expression

Hotspot Mutations

Mutation functional classification

• Endocytosis of collagen (R-HSA-2168880)

• uPAR-mediated signaling (R-HSA-3000171)

• Extracellular matrix organization (R-HSA-1474244)

• Integrin cell surface interactions (R-HSA-216083)

MRC2 (uPARAP/Endo180) is a 180 kDa type I transmembrane receptor with an N-terminal cysteine-rich domain, a fibronectin type II domain, and multiple C-type lectin-like domains. It binds and internalizes collagen for lysosomal degradation, thereby regulating extracellular matrix turnover. The receptor also interacts with urokinase plasminogen activator receptor (uPAR) to modulate cell adhesion and migration. In cancer, MRC2 overexpression facilitates tumor invasion, while loss-of-function mutations cause skeletal defects.