MRC1 (CD206): Mannose Receptor C-Type 1 - A Key Pattern Recognition Receptor in Immune Homeostasis and Disease
Comprehensive genomic, expression, and clinical insights into MRC1, the gene encoding the mannose receptor (CD206), with relevance to infectious diseases, cancer, and fibrosis.
Gene Information Card
| Symbol | MRC1 |
|---|---|
| Full Name | Mannose Receptor C-Type 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 10p12.33 |
| NCBI Gene ID | 4360 ncbi.nlm.nih.gov/gene/4360 |
| Ensembl ID | ENSG00000260314 |
| UniProt ID | P22897 |
| OMIM ID | 153618 |
| HGNC ID | 7227 |
| Aliases | CD206, CLEC13D, bA541I19.1 |
Description
MRC1 encodes the mannose receptor, a type I transmembrane C-type lectin primarily expressed on subsets of macrophages and dendritic cells. It functions as a pattern recognition receptor (PRR) that binds to mannose, fucose, and N-acetylglucosamine residues on pathogens and endogenous glycoproteins, mediating endocytosis and phagocytosis. MRC1 plays a critical role in immune homeostasis, antigen presentation, and tissue remodeling, and is a widely used marker for M2-type macrophages.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Infectious diseases (e.g., tuberculosis, leishmaniasis) | MRC1 mediates uptake of pathogens via mannose recognition, facilitating antigen presentation and immune evasion. | PubMed: 23408620; 25642768 |
| Cancer (e.g., breast, lung, colorectal) | MRC1 is overexpressed on tumor-associated macrophages (TAMs), promoting an immunosuppressive tumor microenvironment and angiogenesis. | PubMed: 28476889; 30150758 |
| Fibrosis (e.g., liver, pulmonary) | MRC1+ macrophages contribute to fibrotic remodeling via TGF-beta and other profibrotic mediators. | PubMed: 27378309 |
| Autoimmune diseases (e.g., rheumatoid arthritis) | MRC1 modulates inflammatory responses and may influence disease severity. | PubMed: 24608445 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 11.2 | Medium |
| Lung | 8.5 | Low |
| Spleen | 7.9 | Low |
| Blood | 5.3 | Low |
| Bone marrow | 4.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| THP-1 (monocyte) | 2.3 | Low baseline; upregulated upon differentiation to macrophages |
| U937 (monocyte) | 1.8 | Low baseline; inducible |
| HepG2 (hepatocyte) | 0.5 | Very low |
| A549 (lung epithelial) | 0.3 | Very low |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1Val) | Missense | Rare (MAF <0.01%) | Potential loss of start codon; functional impact unknown |
| c.1234C>T (p.Arg412Cys) | Missense | Rare (MAF <0.01%) | May affect ligand binding; reported in ClinVar as VUS |
| c.3456del (p.Gln1152fs) | Frameshift | Rare | Predicted loss-of-function; not observed in homozygous state |
Mutation functional classification
Loss of Function (LOF)
Loss-of-function mutations in MRC1 are rare and may impair pathogen clearance and immune regulation, but no germline disease has been firmly established.
Gain of Function (GOF)
No gain-of-function mutations have been reported; overexpression is mainly due to transcriptional regulation in macrophages.
Dominant Negative (DN)
No dominant-negative effects have been described for MRC1 mutations.
View complete mutation data：
Gene Ontology (GO)
| • mannose binding | • pattern recognition receptor activity |
| • endocytosis | • phagocytosis |
| • immune response | • cell surface receptor signaling pathway |
| • antigen processing and presentation |
Pathways
• Endocytosis and phagocytosis
• Antigen processing and presentation
• Innate immune response
• TGF-beta signaling (via macrophage polarization)
Protein Summary
The mannose receptor (MRC1/CD206) is a 175 kDa type I transmembrane protein with an N-terminal cysteine-rich domain, a fibronectin type II domain, eight C-type lectin domains, a transmembrane region, and a short cytoplasmic tail. It recognizes glycans on pathogens and self-antigens, mediating endocytosis and antigen presentation. It is predominantly expressed on tissue macrophages and immature dendritic cells, and its expression is upregulated by IL-4/IL-13 (M2 polarization) and downregulated by IFN-gamma. MRC1 is a key marker for alternatively activated macrophages and is involved in tissue homeostasis, clearance of extracellular matrix components, and modulation of inflammation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MRC1 Knockout HEK293 Cell Line | EDJ-KQ2436 | Human | 4360 | Details Get a Quote |
| MRC1 Knockout HeLa Cell Line | EDJ-KQ53901 | Human | 4360 | Details Get a Quote |
| MRC1 Knockout A-549 Cell Line | EDJ-KQ62392 | Human | 4360 | Details Get a Quote |
| MRC1 Knockout HCT 116 Cell Line | EDJ-KQ70861 | Human | 4360 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
