MPZL1: Myelin Protein Zero Like 1 - A Key Player in Cell Adhesion and Cancer
Comprehensive genomic and proteomic analysis of MPZL1, a transmembrane glycoprotein involved in cell-cell interactions, tumor progression, and metastasis.
Gene Information Card
| Symbol | MPZL1 |
|---|---|
| Full Name | Myelin Protein Zero Like 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 1q24.2 |
| NCBI Gene ID | 9019 ncbi.nlm.nih.gov/gene/9019 |
| Ensembl ID | ENSG00000116285 |
| UniProt ID | O95297 |
| OMIM ID | 604376 |
| HGNC ID | 7226 |
| Aliases | PZR, PZR1, PZRalpha, PZRbeta |
Description
MPZL1 (myelin protein zero like 1) encodes a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The protein functions as a cell adhesion molecule and is involved in cell-cell interactions, signal transduction, and modulation of cell migration. MPZL1 is implicated in tumor progression, particularly in promoting metastasis in various cancers including hepatocellular carcinoma, breast cancer, and colorectal cancer. Alternative splicing generates multiple isoforms.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hepatocellular carcinoma | MPZL1 overexpression promotes cell migration and invasion via Src/FAK signaling | PMID: 25636873 |
| Breast cancer | MPZL1 upregulation correlates with poor prognosis and metastasis through PI3K/Akt pathway | PMID: 27323851 |
| Colorectal cancer | MPZL1 enhances tumor growth and metastasis by activating ERK/MAPK signaling | PMID: 29057924 |
| Gastric cancer | MPZL1 expression associated with lymph node metastasis and reduced survival | PMID: 30348656 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Breast | 8.3 | Low |
| Colon | 15.7 | Medium |
| Lung | 6.2 | Low |
| Kidney | 9.8 | Low |
| Placenta | 20.1 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 (liver cancer) | 18.4 | High expression |
| MCF7 (breast cancer) | 11.2 | Moderate expression |
| HCT116 (colorectal cancer) | 22.7 | High expression |
| A549 (lung cancer) | 7.5 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.245G>A (p.Arg82Gln) | Missense | 0.02% | Altered protein stability and interaction |
| c.512C>T (p.Pro171Leu) | Missense | 0.01% | Potential loss of function |
| c.789_790insA | Frameshift | <0.01% | Truncated protein, likely loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations leading to truncated protein or reduced expression are classified as loss-of-function.
Gain of Function (GOF)
Missense mutations in the extracellular domain may enhance receptor dimerization and signaling, potentially acting as gain-of-function.
Dominant Negative (DN)
No dominant negative mutations have been reported for MPZL1.
View complete mutation data：
Gene Ontology (GO)
| • cell adhesion | • cell-cell signaling |
| • transmembrane signaling receptor activity | • protein binding |
| • plasma membrane | • integral component of membrane |
Pathways
• PI3K-Akt signaling pathway
• Focal adhesion
• ECM-receptor interaction
• Rap1 signaling pathway
Protein Summary
MPZL1 is a type I transmembrane glycoprotein with a single extracellular immunoglobulin-like domain, a transmembrane region, and a cytoplasmic tail containing immunoreceptor tyrosine-based inhibitory motifs (ITIMs). It mediates homophilic and heterophilic cell adhesion, and upon ligand binding, recruits phosphatases such as SHP-2 to modulate downstream signaling cascades including Src/FAK, PI3K/Akt, and ERK/MAPK. The protein is widely expressed in epithelial tissues and is upregulated in multiple cancers, where it promotes cell migration, invasion, and metastasis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MPZL1 Knockout HEK293 Cell Line | EDJ-KQ2422 | Human | 9019 | Details Get a Quote |
| MPZL1 Knockout A-549 Cell Line | EDJ-KQ24301 | Human | 9019 | Details Get a Quote |
| MPZL1 Knockout HCT 116 Cell Line | EDJ-KQ24302 | Human | 9019 | Details Get a Quote |
| MPZL1 Knockout HeLa Cell Line | EDJ-KQ24303 | Human | 9019 | Details Get a Quote |
