MPRIP (Myosin Phosphatase Rho Interacting Protein)
A key regulator of actin cytoskeleton dynamics and cell adhesion
Gene Information Card
| Symbol | MPRIP |
|---|---|
| Full Name | Myosin Phosphatase Rho Interacting Protein |
| Gene Type | Protein coding |
| Chromosomal Location | 17p11.2 |
| NCBI Gene ID | 23164 ncbi.nlm.nih.gov/gene/23164 |
| Ensembl ID | ENSG00000133056 |
| UniProt ID | Q6WCQ1 |
| OMIM ID | 616559 |
| HGNC ID | 30321 |
| Aliases | M-RIP, p116Rip, RhoA-interacting protein |
Description
The MPRIP gene encodes myosin phosphatase Rho interacting protein, a scaffold protein that binds to myosin phosphatase and RhoA. It regulates actomyosin contractility, stress fiber formation, and cell adhesion by modulating myosin light chain phosphorylation. MPRIP is involved in cytoskeletal organization and cell migration.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Amyotrophic lateral sclerosis (ALS) | MPRIP variants may disrupt cytoskeletal dynamics in motor neurons, contributing to neurodegeneration. | ClinVar |
| Cancer (various) | Altered MPRIP expression affects cell adhesion and migration, potentially promoting metastasis. | COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Skeletal muscle | 15.2 | Medium |
| Heart | 12.8 | Medium |
| Brain | 8.5 | Low |
| Lung | 6.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 10.1 | Cervical cancer |
| A549 | 7.4 | Lung cancer |
| HEK 293 | 9.8 | Embryonic kidney |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T | Missense | <0.1% | Unknown functional impact |
| c.567delA | Frameshift | Rare | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift or nonsense mutations that truncate the protein, impairing its scaffold function.
Gain of Function (GOF)
Not well characterized; potential missense variants may alter RhoA binding.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • actin cytoskeleton organization | • cell adhesion |
| • regulation of myosin light chain phosphorylation | • Rho protein signal transduction |
Pathways
• RhoA signaling
• Actin cytoskeleton regulation
• Myosin phosphatase pathway
Protein Summary
MPRIP is a 116 kDa scaffold protein that localizes to stress fibers and focal adhesions. It contains a coiled-coil domain and a RhoA-binding region, linking myosin phosphatase to RhoA to regulate actomyosin contractility. It plays a role in cell shape maintenance and migration.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MPRIP Knockout HEK293 Cell Line | EDJ-KQ2893 | Human | 23164 | Details Get a Quote |
| MPRIP Knockout HCT 116 Cell Line | EDJ-KQ23965 | Human | 23164 | Details Get a Quote |
| MPRIP Knockout HeLa Cell Line | EDJ-KQ23966 | Human | 23164 | Details Get a Quote |
| MPRIP Knockout A-549 Cell Line | EDJ-KQ22592 | Human | 23164 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
