MPPED2
Metallophosphoesterase Domain Containing 2
Gene Information Card
| Symbol | MPPED2 |
|---|---|
| Full Name | Metallophosphoesterase Domain Containing 2 |
| Gene Type | Protein coding |
| Chromosomal Location | 11p14.1 |
| NCBI Gene ID | 781 ncbi.nlm.nih.gov/gene/781 |
| Ensembl ID | ENSG00000110395 |
| UniProt ID | Q9NQ90 |
| OMIM ID | 606868 |
| HGNC ID | 7223 |
| Aliases | C11orf8, FLJ20186, MGC138290, MGC138291 |
Description
MPPED2 encodes a metallophosphoesterase domain-containing protein. The protein is predicted to have phosphoesterase activity and may be involved in cellular signaling or metabolic processes. Expression is observed in various tissues, with notable levels in the brain and kidney.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported in ClinVar or OMIM | Not established | Not available |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Kidney | 8.3 | Medium |
| Liver | 3.1 | Low |
| Heart | 2.0 | Low |
| Lung | 1.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 15.2 | High expression |
| HeLa | 6.7 | Medium expression |
| HepG2 | 4.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported in ClinVar | Not applicable | Not applicable | Not applicable |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • metallophosphoesterase activity | • hydrolase activity |
| • metal ion binding |
Pathways
• No specific pathways annotated
Protein Summary
MPPED2 is a 367-amino acid protein containing a metallophosphoesterase domain. It is predicted to function as a phosphoesterase, potentially involved in dephosphorylation reactions. The protein is localized in the cytoplasm and may play a role in cellular signaling.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MPPED2 Knockout HEK293 Cell Line | EDJ-KQ4167 | Human | 744 | Details Get a Quote |
| MPPED2 Knockout HeLa Cell Line | EDJ-KQ52756 | Human | 744 | Details Get a Quote |
| MPPED2 Knockout A-549 Cell Line | EDJ-KQ61226 | Human | 744 | Details Get a Quote |
| MPPED2 Knockout HCT 116 Cell Line | EDJ-KQ69723 | Human | 744 | Details Get a Quote |
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