MPND Gene
MPN Domain Containing Gene
Gene Information Card
| Symbol | MPND |
|---|---|
| Full Name | MPN domain containing |
| Gene Type | protein-coding |
| Chromosomal Location | 19p13.3 |
| NCBI Gene ID | 84954 ncbi.nlm.nih.gov/gene/84954 |
| Ensembl ID | ENSG00000104879 |
| UniProt ID | Q9H7S9 |
| OMIM ID | 617564 |
| HGNC ID | 25927 |
| Aliases | C19orf6, HSPC049, PRO1855 |
Description
MPND (MPN domain containing) is a protein-coding gene located on chromosome 19p13.3. The encoded protein contains an MPN (Mpr1/Pad1 N-terminal) domain, which is associated with deubiquitinase activity and may play a role in protein degradation pathways. MPND is ubiquitously expressed in various tissues and has been implicated in cellular stress responses.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | N/A | N/A |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 15.2 | Medium |
| Brain | 10.5 | Medium |
| Kidney | 8.3 | Low |
| Liver | 6.1 | Low |
| Heart | 5.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 12.0 | Embryonic kidney |
| HeLa | 9.5 | Cervical carcinoma |
| K562 | 7.8 | Leukemia |
| A549 | 6.2 | Lung carcinoma |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic mutations reported | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • deubiquitinase activity | • protein binding |
| • cytoplasm | • nucleus |
Pathways
• Ubiquitin-proteasome pathway
Protein Summary
The MPND protein contains an MPN domain characteristic of deubiquitinases, suggesting involvement in ubiquitin-dependent processes. It is localized in the cytoplasm and nucleus, and may regulate protein stability and cellular stress responses.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MPND Knockout HEK293 Cell Line | EDJ-KQ3815 | Human | 84954 | Details Get a Quote |
| MPND Knockout HCT 116 Cell Line | EDJ-KQ25942 | Human | 84954 | Details Get a Quote |
| MPND Knockout HeLa Cell Line | EDJ-KQ25943 | Human | 84954 | Details Get a Quote |
| MPND Knockout A-549 Cell Line | EDJ-KQ24584 | Human | 84954 | Details Get a Quote |
| MPND Knockout HAP1 Cell Line | EDC08019 | Human | 84954 | Details Get a Quote |
Displaying Records 1 To 5 Of 5 Records
