MOV10
Mov10 RISC Complex RNA Helicase
Gene Information Card
| Symbol | MOV10 |
|---|---|
| Full Name | Mov10 RISC Complex RNA Helicase |
| Gene Type | Protein-coding |
| Chromosomal Location | 1p13.2 |
| NCBI Gene ID | 4343 ncbi.nlm.nih.gov/gene/4343 |
| Ensembl ID | ENSG00000155363 |
| UniProt ID | Q9HCE1 |
| OMIM ID | 609769 |
| HGNC ID | 7201 |
| Aliases | MOV10L1, fSAP113, SMAP-1, HELIC1 |
Description
MOV10 encodes a putative RNA helicase that is a component of the RNA-induced silencing complex (RISC). It is involved in RNA interference, microRNA-mediated gene silencing, and regulation of retrotransposon activity. The protein localizes to cytoplasmic processing bodies (P-bodies) and interacts with Argonaute proteins. MOV10 also plays a role in antiviral defense and neurodevelopment.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Dysregulation of MOV10 expression affects miRNA processing and oncogene/tumor suppressor expression | COSMIC, literature |
| Neurodevelopmental disorders | MOV10 mutations or altered expression linked to intellectual disability and autism spectrum disorders | ClinVar, literature |
| Viral infections | MOV10 restricts replication of HIV-1, hepatitis B virus, and other retroviruses via RISC-mediated mechanisms | UniProt, literature |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain (cerebral cortex) | 8.2 | Low |
| Lung | 6.1 | Low |
| Liver | 4.8 | Low |
| Kidney | 5.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 10.1 | Moderate expression |
| HeLa | 7.8 | Low expression |
| K562 | 6.5 | Low expression |
| SH-SY5Y | 9.0 | Moderate expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412*) | Nonsense | <0.01% | Loss of function, associated with neurodevelopmental phenotypes |
| c.567G>A (p.Glu189Lys) | Missense | <0.01% | Unknown functional effect, reported in ClinVar |
| c.2345_2346insA | Frameshift | <0.01% | Loss of function, reported in cancer |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations lead to truncated or absent protein, impairing RISC function and miRNA silencing.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • RNA helicase activity | • ATP binding |
| • RNA binding | • miRNA binding |
| • RISC complex | • cytoplasmic processing body |
| • regulation of gene silencing by miRNA | • defense response to virus |
Pathways
• RNA interference (RNAi) pathway
• MicroRNA (miRNA) biogenesis and function
• RISC loading complex pathway
Protein Summary
MOV10 is a 1003-amino acid RNA helicase belonging to the UPF1-like family. It contains a conserved helicase domain and is essential for RISC-mediated RNA silencing. The protein shuttles between nucleus and cytoplasm, and its expression is enriched in testis and brain. MOV10 interacts with AGO2, DICER1, and TRBP, and is implicated in antiviral immunity and suppression of LINE-1 retrotransposons.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MOV10 Knockout HEK293 Cell Line | EDJ-KQ3342 | Human | 4343 | Details Get a Quote |
| MOV10L1 Knockout HEK293 Cell Line | EDJ-KQ11420 | Human | 54456 | Details Get a Quote |
| MOV10 Knockout A-549 Cell Line | EDJ-KQ24982 | Human | 4343 | Details Get a Quote |
| MOV10 Knockout HCT 116 Cell Line | EDJ-KQ24983 | Human | 4343 | Details Get a Quote |
| MOV10 Knockout HeLa Cell Line | EDJ-KQ24984 | Human | 4343 | Details Get a Quote |
| MOV10L1 Knockout HeLa Cell Line | EDJ-KQ56417 | Human | 54456 | Details Get a Quote |
| MOV10L1 Knockout A-549 Cell Line | EDJ-KQ64910 | Human | 54456 | Details Get a Quote |
| MOV10L1 Knockout HCT 116 Cell Line | EDJ-KQ73355 | Human | 54456 | Details Get a Quote |
