MORF4L1 Gene - Mortality Factor 4 Like 1
A chromatin-binding protein involved in transcriptional regulation, DNA repair, and cell cycle control.
Gene Information Card
| Symbol | MORF4L1 |
|---|---|
| Full Name | Mortality Factor 4 Like 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 15q25.1 |
| NCBI Gene ID | 10933 ncbi.nlm.nih.gov/gene/10933 |
| Ensembl ID | ENSG00000185787 |
| UniProt ID | Q9UBU8 |
| OMIM ID | 607599 |
| HGNC ID | 24815 |
| Aliases | MRG15, FWP006, HsT17725, MORF4L1B |
Description
MORF4L1 (Mortality Factor 4 Like 1) encodes a member of the MORF4/MRG family of transcription regulatory proteins. The protein contains a chromodomain and is a component of several histone acetyltransferase (HAT) complexes, including the NuA4/TIP60 complex. It plays roles in chromatin remodeling, transcriptional activation and repression, DNA damage repair, and cell cycle regulation. MORF4L1 is ubiquitously expressed and has been implicated in cellular senescence and cancer.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Altered expression and interaction with oncogenic pathways; potential role in tumor suppression | PMID: 15601826 |
| Colorectal cancer | Dysregulation of MORF4L1 expression associated with tumor progression | PMID: 21502544 |
| Prostate cancer | MORF4L1 overexpression linked to poor prognosis and androgen receptor signaling | PMID: 23708656 |
| Lung cancer | MORF4L1 mutations and copy number alterations observed in lung adenocarcinoma | COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 18.5 | High |
| Bone marrow | 12.3 | Medium |
| Lymph node | 11.8 | Medium |
| Brain | 9.2 | Medium |
| Liver | 6.7 | Low |
| Heart | 5.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 15.2 | Embryonic kidney; high expression |
| HeLa | 13.8 | Cervical carcinoma; high expression |
| K562 | 11.5 | Leukemia; medium expression |
| HepG2 | 9.1 | Hepatocellular carcinoma; medium expression |
| A549 | 7.3 | Lung carcinoma; low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.487C>T (p.Arg163Trp) | Missense | <0.01% | Unknown; likely benign |
| c.632A>G (p.Gln211Arg) | Missense | <0.01% | Unknown; likely benign |
| c.1A>G (p.Met1Val) | Missense | <0.01% | Potential loss of start codon |
| c.1072C>T (p.Arg358*) | Nonsense | <0.01% | Truncation; likely loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations (e.g., p.Arg358*) are predicted to cause loss of function by truncating the protein.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • chromatin binding (GO:0003682) | • protein binding (GO:0005515) |
| • chromatin organization (GO:0006325) | • transcription (GO:0006351) |
| • DNA repair (GO:0006281) | • nucleus (GO:0005634) |
Pathways
• NuA4 histone acetyltransferase complex
• TIP60 complex
• DNA damage response
• Chromatin remodeling
Protein Summary
MORF4L1 (MRG15) is a 323-amino-acid protein containing an N-terminal chromodomain that mediates binding to methylated histones (e.g., H3K36me3). It is a core component of the NuA4/TIP60 HAT complex, which acetylates histones and non-histone proteins to regulate transcription, DNA repair, and cell cycle progression. The protein also interacts with other chromatin modifiers and transcription factors, influencing cellular senescence and proliferation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MORF4L1 Knockout HEK293 Cell Line | EDJ-KQ51023 | Human | 10933 | Details Get a Quote |
| MORF4L1 Knockout HeLa Cell Line | EDJ-KQ55532 | Human | 10933 | Details Get a Quote |
| MORF4L1 Knockout A-549 Cell Line | EDJ-KQ64022 | Human | 10933 | Details Get a Quote |
| MORF4L1 Knockout HCT 116 Cell Line | EDJ-KQ72473 | Human | 10933 | Details Get a Quote |
