MORC4 Gene
MORC Family CW-Type Zinc Finger 4
Gene Information Card
| Symbol | MORC4 |
|---|---|
| Full Name | MORC family CW-type zinc finger 4 |
| Gene Type | Protein coding |
| Chromosomal Location | Xq22.1 |
| NCBI Gene ID | 79710 ncbi.nlm.nih.gov/gene/79710 |
| Ensembl ID | ENSG00000133131 |
| UniProt ID | Q8TE76 |
| OMIM ID | 300169 |
| HGNC ID | 23529 |
| Aliases | KIAA0852, ZCW4, MORC-4 |
Description
MORC4 is a protein-coding gene located on the X chromosome. It belongs to the MORC (microrehidia) family of proteins, characterized by a CW-type zinc finger domain. The encoded protein is involved in transcriptional regulation, chromatin remodeling, and DNA repair. MORC4 is expressed in various tissues and has been implicated in cancer and immune-related processes.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Altered expression may contribute to tumorigenesis via chromatin dysregulation | COSMIC; PMID: 25691885 |
| Colorectal cancer | MORC4 overexpression associated with poor prognosis | COSMIC; PMID: 29348694 |
| Prostate cancer | Potential role in androgen receptor signaling | COSMIC; PMID: 27557537 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Lymph node | 8.2 | Low |
| Spleen | 7.1 | Low |
| Bone marrow | 6.8 | Low |
| Brain | 3.4 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.3 | Embryonic kidney cells |
| HeLa | 10.1 | Cervical cancer cells |
| MCF7 | 8.7 | Breast cancer cells |
| K562 | 6.2 | Leukemia cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T | Missense | 0.01% | p.Arg412Cys; ClinVar uncertain significance |
| c.567_568del | Frameshift | <0.01% | Loss of function; COSMIC |
| c.890A>G | Missense | 0.02% | p.Gln297Arg; COSMIC |
Mutation functional classification
Loss of Function (LOF)
Frameshift deletions (e.g., c.567_568del) predicted to truncate the protein, impairing chromatin binding.
Gain of Function (GOF)
Not well characterized; some missense variants may alter protein stability.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • DNA binding (GO:0003677) | • protein binding (GO:0005515) |
| • nucleus (GO:0005634) | • chromatin organization (GO:0006325) |
| • regulation of transcription (GO:0006355) |
Pathways
• Chromatin remodeling
• DNA damage response
Protein Summary
The MORC4 protein contains a CW-type zinc finger domain that mediates interaction with methylated histones and chromatin. It is localized to the nucleus and participates in transcriptional repression and DNA repair. The protein is 1030 amino acids long with a molecular weight of approximately 115 kDa.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MORC4 Knockout HEK293 Cell Line | EDJ-KQ14285 | Human | 79710 | Details Get a Quote |
| MORC4 Knockout HCT 116 Cell Line | EDJ-KQ43110 | Human | 79710 | Details Get a Quote |
| MORC4 Knockout A-549 Cell Line | EDJ-KQ44328 | Human | 79710 | Details Get a Quote |
| MORC4 Knockout HeLa Cell Line | EDJ-KQ44329 | Human | 79710 | Details Get a Quote |
| MORC4（p.S734A, c.2200T>G） Point Mutation in SW480 Cell Line | EDC90606 | Human | 79710 | Details Get a Quote |
