MOGAT1
Monoacylglycerol O-Acyltransferase 1
Gene Information Card
| Symbol | MOGAT1 |
|---|---|
| Full Name | Monoacylglycerol O-Acyltransferase 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 2q36.3 |
| NCBI Gene ID | 116255 ncbi.nlm.nih.gov/gene/116255 |
| Ensembl ID | ENSG00000163082 |
| UniProt ID | Q96PD6 |
| OMIM ID | 610951 |
| HGNC ID | 23254 |
| Aliases | MGAT1, DGAT1L, MOGAT |
Description
MOGAT1 encodes monoacylglycerol O-acyltransferase 1, an enzyme that catalyzes the synthesis of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. This reaction is a key step in the monoacylglycerol pathway for triacylglycerol synthesis, primarily in the small intestine. The protein is localized to the endoplasmic reticulum membrane and plays a role in dietary fat absorption and lipid metabolism.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Obesity | Altered MOGAT1 expression may affect triacylglycerol synthesis and fat storage, contributing to obesity risk. | Association studies (PMID: 19696716) |
| Hypertriglyceridemia | Increased MOGAT1 activity may elevate postprandial triglyceride levels. | Expression analysis in intestinal biopsies (PMID: 21700725) |
| Non-alcoholic fatty liver disease (NAFLD) | MOGAT1 upregulation in liver may promote hepatic steatosis via increased triacylglycerol synthesis. | Animal model studies (PMID: 24847884) |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Small intestine | 45.2 | High |
| Colon | 12.8 | Medium |
| Stomach | 8.5 | Low |
| Liver | 3.1 | Low |
| Adipose tissue | 1.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Caco-2 | 38.7 | Intestinal epithelial cell line; high expression |
| HepG2 | 2.4 | Hepatocellular carcinoma; low expression |
| HT-29 | 15.3 | Colorectal adenocarcinoma; moderate expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.419C>T (p.Pro140Leu) | missense | <0.01% | Unknown functional impact; rare population variant |
| c.722G>A (p.Arg241Gln) | missense | <0.01% | Predicted benign by SIFT; no known disease association |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in MOGAT1.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • acyltransferase activity | • diacylglycerol O-acyltransferase activity |
| • endoplasmic reticulum membrane | • lipid metabolic process |
| • triacylglycerol biosynthetic process |
Pathways
• Glycerolipid metabolism (Reactome: R-HSA-8978868)
• Triacylglycerol synthesis (KEGG: hsa00561)
Protein Summary
Monoacylglycerol O-acyltransferase 1 (MOGAT1) is a 335-amino acid integral membrane protein of the endoplasmic reticulum. It belongs to the diacylglycerol acyltransferase (DGAT) family and catalyzes the conversion of 2-monoacylglycerol and fatty acyl-CoA to diacylglycerol. This enzyme is essential for the monoacylglycerol pathway of triacylglycerol synthesis, predominantly active in the small intestine during dietary fat absorption. MOGAT1 shares sequence similarity with DGAT1 but has distinct substrate specificity.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MOGAT1 Knockout HEK293 Cell Line | EDJ-KQ7560 | Human | 116255 | Details Get a Quote |
| MOGAT1 Knockout HeLa Cell Line | EDJ-KQ57977 | Human | 116255 | Details Get a Quote |
| MOGAT1 Knockout A-549 Cell Line | EDJ-KQ66466 | Human | 116255 | Details Get a Quote |
| MOGAT1 Knockout HCT 116 Cell Line | EDJ-KQ74887 | Human | 116255 | Details Get a Quote |
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