MOB4: A Core Component of the Hippo Signaling Pathway
Comprehensive genomic and proteomic analysis of MOB4, a key regulator of cell proliferation and apoptosis.
Gene Information Card
| Symbol | MOB4 |
|---|---|
| Full Name | MOB family member 4, phocein |
| Gene Type | protein-coding |
| Chromosomal Location | 2q33.2 |
| NCBI Gene ID | 25843 ncbi.nlm.nih.gov/gene/25843 |
| Ensembl ID | ENSG00000115956 |
| UniProt ID | Q9H8S9 |
| OMIM ID | 609361 |
| HGNC ID | 18292 |
| Aliases | MOBKL3, MOB1B, MOB2B, PHOCEIN |
Description
MOB4 (MOB family member 4, phocein) encodes a protein that belongs to the MOB family of co-activators, which are essential components of the Hippo signaling pathway. The protein interacts with serine/threonine kinases such as MST1/2 and NDR1/2, regulating cell proliferation, apoptosis, and organ size control. MOB4 is ubiquitously expressed and plays a role in neuronal development and cancer.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Dysregulation of Hippo pathway via altered MOB4 expression or mutation leads to uncontrolled cell proliferation and reduced apoptosis. | COSMIC, ClinVar |
| Neurodevelopmental disorders | MOB4 interacts with NDR kinases involved in neuronal morphogenesis; mutations may disrupt brain development. | OMIM, UniProt |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Lung | 8.3 | Low |
| Liver | 6.1 | Low |
| Kidney | 9.7 | Low |
| Testis | 15.2 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 10.4 | Embryonic kidney |
| HeLa | 7.8 | Cervical cancer |
| A549 | 6.5 | Lung cancer |
| MCF7 | 9.1 | Breast cancer |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.287G>A (p.Arg96Gln) | Missense | 0.02% | Unknown functional impact |
| c.421C>T (p.Arg141Trp) | Missense | 0.01% | Potential loss of function |
| c.544_545insA | Frameshift | <0.01% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations predicted to truncate the protein, impairing Hippo signaling.
Gain of Function (GOF)
Not reported in MOB4.
Dominant Negative (DN)
Not reported in MOB4.
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) | • cytosol (GO:0005829) |
| • intracellular signal transduction (GO:0035556) | • identical protein binding (GO:0042802) |
| • cellular response to radiation (GO:0071478) |
Pathways
• Hippo signaling pathway (KEGG: hsa04390)
• MST1/MST2-NDR1/NDR2 signaling
Protein Summary
MOB4 is a 216-amino-acid protein (UniProt Q9H8S9) that functions as a co-activator in the Hippo signaling cascade. It binds to and activates NDR1/2 and MST1/2 kinases, promoting phosphorylation of downstream targets such as YAP1. The protein is localized in the cytosol and is involved in cell cycle regulation, apoptosis, and tissue homeostasis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MOB4 Knockout HEK293 Cell Line | EDJ-KQ51141 | Human | 25843 | Details Get a Quote |
| HSPE1-MOB4 Knockout HEK293 Cell Line | EDJ-KQ52497 | Human | 100529241 | Details Get a Quote |
| MOB4 Knockout HeLa Cell Line | EDJ-KQ55830 | Human | 25843 | Details Get a Quote |
| HSPE1-MOB4 Knockout HeLa Cell Line | EDJ-KQ60960 | Human | 100529241 | Details Get a Quote |
| MOB4 Knockout A-549 Cell Line | EDJ-KQ64322 | Human | 25843 | Details Get a Quote |
| HSPE1-MOB4 Knockout A-549 Cell Line | EDJ-KQ69435 | Human | 100529241 | Details Get a Quote |
| MOB4 Knockout HCT 116 Cell Line | EDJ-KQ72775 | Human | 25843 | Details Get a Quote |
| HSPE1-MOB4 Knockout HCT 116 Cell Line | EDJ-KQ77786 | Human | 100529241 | Details Get a Quote |
