MOB2 Gene - Mps One Binder Kinase Activator-Like 2
A key regulator of Hippo signaling and cell cycle control
Gene Information Card
| Symbol | MOB2 |
|---|---|
| Full Name | MOB (Mps One Binder) Kinase Activator-Like 2 |
| Gene Type | Protein-coding |
| Chromosomal Location | 11p15.5 |
| NCBI Gene ID | 55233 ncbi.nlm.nih.gov/gene/55233 |
| Ensembl ID | ENSG00000148773 |
| UniProt ID | Q96B97 |
| OMIM ID | 609302 |
| HGNC ID | 16758 |
| Aliases | MOBKL2, MOB1C, MOB2A, MOB2B |
Description
MOB2 encodes a member of the MOB family of proteins that function as co-activators of NDR/LATS kinases in the Hippo signaling pathway. MOB2 specifically interacts with and activates STK38 (NDR1) and STK38L (NDR2), regulating cell cycle progression, centrosome duplication, and cell proliferation. It is involved in the control of mitotic exit and cytokinesis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | Dysregulation of Hippo pathway via altered MOB2 expression | COSMIC, PubMed |
| Colorectal cancer | MOB2 overexpression linked to poor prognosis | PubMed |
| Breast cancer | MOB2 amplification and overexpression observed | COSMIC, PubMed |
| Lung cancer | MOB2 mutations and altered expression | COSMIC, PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Lymph node | 9.8 | Medium |
| Spleen | 8.2 | Medium |
| Bone marrow | 7.1 | Low |
| Brain | 4.3 | Low |
| Liver | 2.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.2 | High expression |
| HeLa | 10.5 | Moderate expression |
| A549 | 8.9 | Moderate expression |
| MCF7 | 6.3 | Low expression |
| HepG2 | 4.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <1% | Unknown |
| c.100C>T | Nonsense | <1% | Loss of function |
| c.200_201insA | Frameshift | <1% | Loss of function |
| c.300G>A | Missense | <1% | Unknown |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations in MOB2 are predicted to cause loss of function, impairing NDR kinase activation and Hippo signaling.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in MOB2.
Dominant Negative (DN)
No dominant-negative mutations described for MOB2.
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) | • protein kinase binding (GO:0019901) |
| • hippo signaling (GO:0035329) | • cell division (GO:0051301) |
| • centrosome cycle (GO:0007098) | • cell cycle (GO:0007049) |
Pathways
• Hippo signaling pathway (KEGG: hsa04390)
• NDR kinase activation pathway
• Cell cycle regulation
Protein Summary
MOB2 is a 216-amino acid protein (25.5 kDa) that contains a conserved MOB domain. It functions as a co-activator of NDR1/NDR2 kinases, promoting their autophosphorylation and activation. MOB2 localizes to the centrosome and midbody, playing a critical role in mitotic progression and cytokinesis. Its expression is tightly regulated during the cell cycle.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MOB2 Knockout HEK293 Cell Line | EDJ-KQ9702 | Human | 81532 | Details Get a Quote |
| MOB2 Knockout HeLa Cell Line | EDJ-KQ35256 | Human | 81532 | Details Get a Quote |
| MOB2 Knockout A-549 Cell Line | EDJ-KQ36474 | Human | 81532 | Details Get a Quote |
| MOB2 Knockout HCT 116 Cell Line | EDJ-KQ36475 | Human | 81532 | Details Get a Quote |
