MOB1B
MOB kinase activator 1B
Gene Information Card
| Symbol | MOB1B |
|---|---|
| Full Name | MOB kinase activator 1B |
| Gene Type | protein-coding |
| Chromosomal Location | 4q13.3 |
| NCBI Gene ID | 55233 ncbi.nlm.nih.gov/gene/55233 |
| Ensembl ID | ENSG00000138685 |
| UniProt ID | Q7L9L4 |
| OMIM ID | 609287 |
| HGNC ID | 29802 |
| Aliases | MOB4B, MOBKL1B, MOB1B, MOB1, MOB1A |
Description
MOB1B (MOB kinase activator 1B) is a protein-coding gene that encodes a component of the Hippo signaling pathway. The protein binds to and activates the serine/threonine kinases STK3 (MST2) and STK4 (MST1), which in turn phosphorylate and activate LATS1/2 kinases. This cascade regulates cell proliferation, apoptosis, and organ size. MOB1B is widely expressed and plays a role in cell cycle control and tumor suppression.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal cancer | Loss of MOB1B expression leads to impaired Hippo signaling, increased YAP/TAZ activity, and enhanced cell proliferation. | PMID: 25605248 |
| Hepatocellular carcinoma | Reduced MOB1B levels correlate with poor prognosis and activation of oncogenic YAP signaling. | PMID: 28991257 |
| Breast cancer | MOB1B downregulation promotes cell migration and invasion via Hippo pathway dysregulation. | PMID: 30108144 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 14.2 | Medium |
| Liver | 11.8 | Medium |
| Kidney | 9.5 | Low |
| Heart | 7.3 | Low |
| Testis | 20.1 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.3 | Embryonic kidney cells |
| HeLa | 12.1 | Cervical cancer cells |
| HepG2 | 10.5 | Hepatocellular carcinoma cells |
| MCF7 | 8.9 | Breast cancer cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | <0.1% | Loss of start codon, likely loss of function |
| c.205C>T (p.Arg69Trp) | Missense | <0.1% | Unknown significance |
| c.346G>A (p.Glu116Lys) | Missense | <0.1% | Unknown significance |
Mutation functional classification
Loss of Function (LOF)
Loss-of-function mutations in MOB1B impair Hippo signaling, leading to increased YAP/TAZ activity and oncogenic transformation.
Gain of Function (GOF)
No gain-of-function mutations have been reported for MOB1B.
Dominant Negative (DN)
No dominant-negative mutations have been characterized for MOB1B.
View complete mutation data：
Gene Ontology (GO)
| • protein kinase activator activity | • signal transduction |
| • Hippo signaling | • cell cycle |
| • apoptosis | • protein binding |
Pathways
• Hippo signaling pathway (KEGG: hsa04390)
• MST1/MST2 signaling
Protein Summary
MOB1B is a 216-amino-acid protein that functions as a co-activator of MST1/2 kinases. It contains a conserved MOB1/phocein domain and is essential for Hippo pathway activation. The protein localizes to the cytoplasm and nucleus, and its interaction with MST1/2 promotes LATS1/2 phosphorylation. MOB1B is ubiquitously expressed with highest levels in testis and brain.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MOB1B Knockout HEK293 Cell Line | EDJ-KQ1377 | Human | 92597 | Details Get a Quote |
| MOB1B Knockout HCT 116 Cell Line | EDJ-KQ19536 | Human | 92597 | Details Get a Quote |
| MOB1B Knockout A-549 Cell Line | EDJ-KQ20880 | Human | 92597 | Details Get a Quote |
| MOB1B Knockout HeLa Cell Line | EDJ-KQ20881 | Human | 92597 | Details Get a Quote |
