MOAP1 Gene
Modulator of Apoptosis 1
Gene Information Card
| Symbol | MOAP1 |
|---|---|
| Full Name | Modulator of Apoptosis 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 14q32.12 |
| NCBI Gene ID | 64112 ncbi.nlm.nih.gov/gene/64112 |
| Ensembl ID | ENSG00000100888 |
| UniProt ID | Q96BY2 |
| OMIM ID | 609485 |
| HGNC ID | 29658 |
| Aliases | MAP-1, PNMA4 |
Description
MOAP1 (Modulator of Apoptosis 1) encodes a protein that interacts with BAX and activates apoptosis. It is involved in the intrinsic apoptotic pathway and is regulated by RASSF1A. MOAP1 is implicated in cancer and neurodegenerative diseases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal Cancer | MOAP1 downregulation reduces BAX activation, promoting cell survival | PMID: 19029980 |
| Hepatocellular Carcinoma | Loss of MOAP1 expression correlates with poor prognosis and resistance to apoptosis | PMID: 23376921 |
| Lung Cancer | MOAP1 methylation silences expression, impairing apoptosis | PMID: 21502544 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 8.2 | Medium |
| Brain | 6.5 | Medium |
| Liver | 4.1 | Low |
| Colon | 3.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 7.0 | High expression |
| HeLa | 5.2 | Moderate expression |
| HepG2 | 3.5 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.01% | Unknown functional effect |
| c.200C>T | Nonsense | <0.01% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations leading to truncated protein and loss of pro-apoptotic activity.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • apoptotic process (GO:0006915) | • identical protein binding (GO:0042802) |
| • neuron apoptotic process (GO:0051402) | • cytosol (GO:0005829) |
Pathways
• Intrinsic Apoptosis Pathway
• RASSF1A-mediated apoptosis
Protein Summary
MOAP1 is a 351-amino acid protein that localizes to the cytosol and mitochondria. It contains a BH3-like domain and binds BAX, promoting its conformational change and mitochondrial outer membrane permeabilization. MOAP1 is a key effector of RASSF1A-induced apoptosis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MOAP1 Knockout HEK293 Cell Line | EDJ-KQ14280 | Human | 64112 | Details Get a Quote |
| MOAP1 Knockout A-549 Cell Line | EDJ-KQ44316 | Human | 64112 | Details Get a Quote |
| MOAP1 Knockout HCT 116 Cell Line | EDJ-KQ44317 | Human | 64112 | Details Get a Quote |
| MOAP1 Knockout HeLa Cell Line | EDJ-KQ44318 | Human | 64112 | Details Get a Quote |
