MNT
MAX Network Transcriptional Repressor
Gene Information Card
| Symbol | MNT |
|---|---|
| Full Name | MAX network transcriptional repressor |
| Gene Type | protein-coding |
| Chromosomal Location | 17p13.3 |
| NCBI Gene ID | 4335 ncbi.nlm.nih.gov/gene/4335 |
| Ensembl ID | ENSG00000170448 |
| UniProt ID | Q99503 |
| OMIM ID | 603039 |
| HGNC ID | 7185 |
| Aliases | ROX, MXD6, bHLHd3 |
Description
MNT (MAX network transcriptional repressor) is a member of the MAX-interacting transcriptional repressor network. It functions as a transcriptional repressor by forming heterodimers with MAX and binding to E-box DNA sequences, thereby antagonizing MYC-mediated transcriptional activation. MNT plays a critical role in cell cycle regulation, apoptosis, and differentiation. Its dysregulation is implicated in various cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | MNT overexpression or loss contributes to MYC pathway dysregulation | PMID: 19029980 |
| Colorectal cancer | MNT downregulation leads to increased MYC activity and proliferation | PMID: 21502568 |
| Lung cancer | MNT mutations and altered expression associated with tumor progression | COSMIC v99 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Heart | 8.3 | Low |
| Liver | 6.1 | Low |
| Lung | 9.7 | Low |
| Kidney | 11.2 | Medium |
| Testis | 15.8 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 14.2 | Embryonic kidney |
| HeLa | 11.5 | Cervical carcinoma |
| A549 | 9.8 | Lung carcinoma |
| MCF7 | 13.1 | Breast carcinoma |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.01% | p.Met1Val; potential loss of start codon |
| c.200C>T | nonsense | <0.01% | p.Gln67*; premature truncation |
| c.350G>A | missense | <0.01% | p.Arg117His; altered DNA binding |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations leading to truncated protein or loss of MAX interaction.
Gain of Function (GOF)
Not well documented; some missense variants may alter repressor activity.
Dominant Negative (DN)
Mutations that impair dimerization with MAX could act in a dominant-negative manner.
View complete mutation data：
Gene Ontology (GO)
Pathways
• MYC/Max/Mad network
• Transcriptional regulation by MNT
• Cell cycle regulation
Protein Summary
MNT is a 591-amino acid protein containing a basic helix-loop-helix (bHLH) domain and a leucine zipper (LZ) motif. It heterodimerizes with MAX to bind E-box sequences (CACGTG) and repress transcription. MNT lacks a canonical Sin3-interacting domain found in other MXD proteins, suggesting a distinct repression mechanism. It is ubiquitously expressed and regulates cell proliferation, differentiation, and apoptosis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MNT Knockout HeLa Cell Line | EDJ-KQ28251 | Human | 4335 | Details Get a Quote |
| MNT Knockout HCT 116 Cell Line | EDJ-KQ28250 | Human | 4335 | Details Get a Quote |
| MNT Knockout A-549 Cell Line | EDJ-KQ28249 | Human | 4335 | Details Get a Quote |
| MNT Knockout HEK293 Cell Line | EDJ-KQ5227 | Human | 4335 | Details Get a Quote |
