MMP27: Matrix Metallopeptidase 27
A member of the matrix metalloproteinase family involved in extracellular matrix remodeling and potential roles in cancer and inflammatory diseases.
Gene Information Card
| Symbol | MMP27 |
|---|---|
| Full Name | Matrix Metallopeptidase 27 |
| Gene Type | Protein coding |
| Chromosomal Location | 11q22.2 |
| NCBI Gene ID | 64066 ncbi.nlm.nih.gov/gene/64066 |
| Ensembl ID | ENSG00000137673 |
| UniProt ID | Q9H306 |
| OMIM ID | 609246 |
| HGNC ID | 14248 |
| Aliases | MMP-27, MMP27 (matrix metalloproteinase 27) |
Description
MMP27 (matrix metallopeptidase 27) encodes a member of the matrix metalloproteinase (MMP) family, zinc-dependent endopeptidases that degrade extracellular matrix components. MMP27 is involved in tissue remodeling, wound healing, and inflammatory responses. It is expressed in various tissues and has been implicated in cancer progression and inflammatory diseases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | MMP27 overexpression may promote tumor invasion and metastasis through ECM degradation. | NCBI Gene, COSMIC |
| Inflammatory diseases | MMP27 contributes to tissue remodeling and inflammation via ECM breakdown. | NCBI Gene, UniProt |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 0.8 | Low |
| Kidney | 0.6 | Low |
| Testis | 0.5 | Low |
| Spleen | 0.4 | Low |
| Liver | 0.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 0.2 | Low expression |
| HEK293 | 0.1 | Very low expression |
| A549 | 0.3 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.01% | Unknown |
| c.100C>T | Missense | <0.01% | Unknown |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • metalloendopeptidase activity (GO:0004222) | • extracellular matrix (GO:0005578) |
| • proteolysis (GO:0006508) | • collagen catabolic process (GO:0030574) |
| • zinc ion binding (GO:0008270) |
Pathways
• Matrix metalloproteinases (MMPs) pathway
• Extracellular matrix organization
Protein Summary
MMP27 is a secreted matrix metalloproteinase that degrades components of the extracellular matrix, including collagens and gelatin. It contains a signal peptide, a prodomain, a catalytic domain with zinc-binding motif, and a hemopexin-like domain. The protein is involved in tissue remodeling and may play a role in cancer metastasis and inflammation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MMP27 Knockout HEK293 Cell Line | EDJ-KQ13489 | Human | 64066 | Details Get a Quote |
| MMP27 Knockout HeLa Cell Line | EDJ-KQ57013 | Human | 64066 | Details Get a Quote |
| MMP27 Knockout A-549 Cell Line | EDJ-KQ65520 | Human | 64066 | Details Get a Quote |
| MMP27 Knockout HCT 116 Cell Line | EDJ-KQ73954 | Human | 64066 | Details Get a Quote |
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