MMP26: Matrix Metallopeptidase 26
A member of the matrix metalloproteinase family involved in extracellular matrix remodeling and cancer progression.
Gene Information Card
| Symbol | MMP26 |
|---|---|
| Full Name | Matrix Metallopeptidase 26 |
| Gene Type | Protein coding |
| Chromosomal Location | 11p15.4 |
| NCBI Gene ID | 56547 ncbi.nlm.nih.gov/gene/56547 |
| Ensembl ID | ENSG00000167768 |
| UniProt ID | Q9NRE1 |
| OMIM ID | 606426 |
| HGNC ID | 7157 |
| Aliases | Matrilysin-2, Endometase |
Description
MMP26 encodes a member of the matrix metalloproteinase (MMP) family, which are zinc-dependent endopeptidases involved in the degradation of extracellular matrix components. MMP26, also known as matrilysin-2 or endometase, is primarily expressed in epithelial tissues and plays a role in tissue remodeling, wound healing, and tumor invasion. It is frequently upregulated in various cancers and has been implicated in cancer progression and metastasis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Endometrial Cancer | Overexpression of MMP26 promotes invasion and metastasis via ECM degradation. | PMID: 15604244 |
| Breast Cancer | MMP26 expression correlates with poor prognosis and increased tumor aggressiveness. | PMID: 16982746 |
| Prostate Cancer | MMP26 is upregulated and associated with advanced disease stages. | PMID: 17344455 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Endometrium | 12.5 | Medium |
| Placenta | 8.3 | Low |
| Prostate | 6.1 | Low |
| Breast | 4.2 | Low |
| Lung | 3.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 15.2 | Cervical cancer cell line |
| MCF-7 | 9.8 | Breast cancer cell line |
| PC-3 | 7.5 | Prostate cancer cell line |
| A549 | 4.1 | Lung cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.01% | p.Met1Val; potential loss of start codon |
| c.214G>A | Missense | <0.01% | p.Gly72Arg; unknown significance |
| c.389C>T | Nonsense | <0.01% | p.Arg130*; predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations (e.g., p.Arg130*) likely result in truncated, non-functional protein.
Gain of Function (GOF)
No gain-of-function mutations reported in COSMIC or ClinVar.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
| • Metalloendopeptidase activity (GO:0004222) | • Extracellular matrix (GO:0005578) |
| • Collagen catabolic process (GO:0030574) | • Proteolysis (GO:0006508) |
| • Cell adhesion (GO:0007155) |
Pathways
• ['Matrix Metalloproteinases'
• 'REACT:14797']
• ['Degradation of the extracellular matrix'
• 'REACT:118779']
Protein Summary
MMP26 is a 261-amino acid protein with a predicted molecular weight of 28.9 kDa. It contains a signal peptide, a prodomain with a cysteine switch, and a catalytic domain with the zinc-binding motif HExxHxxGxxH. Unlike other MMPs, MMP26 lacks a hemopexin-like domain. It is secreted as a zymogen and activated by proteolytic removal of the prodomain. MMP26 cleaves type IV collagen, fibronectin, and gelatin, contributing to extracellular matrix remodeling.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MMP26 Knockout HEK293 Cell Line | EDJ-KQ12021 | Human | 56547 | Details Get a Quote |
| MMP26 Knockout HeLa Cell Line | EDJ-KQ56740 | Human | 56547 | Details Get a Quote |
| MMP26 Knockout A-549 Cell Line | EDJ-KQ65245 | Human | 56547 | Details Get a Quote |
| MMP26 Knockout HCT 116 Cell Line | EDJ-KQ73686 | Human | 56547 | Details Get a Quote |
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