MMP25: Matrix Metallopeptidase 25
A membrane-type matrix metalloproteinase involved in inflammation and cancer progression
Gene Information Card
| Symbol | MMP25 |
|---|---|
| Full Name | Matrix Metallopeptidase 25 |
| Gene Type | protein-coding |
| Chromosomal Location | 16p13.3 |
| NCBI Gene ID | 64386 ncbi.nlm.nih.gov/gene/64386 |
| Ensembl ID | ENSG00000100033 |
| UniProt ID | Q9NPA2 |
| OMIM ID | 608416 |
| HGNC ID | 14246 |
| Aliases | MT6-MMP, MMP-25, leukolysin |
Description
MMP25 (Matrix Metallopeptidase 25) encodes a member of the matrix metalloproteinase (MMP) family, specifically a membrane-type MMP (MT6-MMP). The protein is anchored to the cell membrane via a glycosylphosphatidylinositol (GPI) anchor and is involved in extracellular matrix degradation, cell migration, and inflammatory responses. It is predominantly expressed in leukocytes and plays a role in neutrophil degranulation and tumor invasion.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal Cancer | Overexpression of MMP25 promotes tumor invasion and metastasis through ECM degradation and activation of pro-MMP2. | PMID: 19029910 |
| Inflammatory Bowel Disease | MMP25 is upregulated in inflamed colonic mucosa and contributes to tissue remodeling and leukocyte infiltration. | PMID: 16959936 |
| Lung Cancer | Elevated MMP25 expression correlates with poor prognosis and increased metastatic potential in non-small cell lung cancer. | PMID: 23327982 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Bone Marrow | 12.5 | Medium |
| Spleen | 8.3 | Low |
| Lung | 6.1 | Low |
| Colon | 4.2 | Low |
| Whole Blood | 3.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HL-60 (leukemia) | 15.2 | High expression |
| THP-1 (monocytic) | 10.8 | Moderate expression |
| A549 (lung carcinoma) | 2.1 | Low expression |
| HCT116 (colorectal) | 1.5 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.487G>A (p.Gly163Arg) | Missense | <0.01% | Unknown functional effect |
| c.1022C>T (p.Thr341Met) | Missense | <0.01% | Reported in COSMIC as likely benign |
| c.1246_1248del (p.Phe416del) | In-frame deletion | <0.01% | May affect GPI anchor attachment |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
| • metalloendopeptidase activity | • extracellular matrix disassembly |
| • proteolysis | • cell migration |
| • neutrophil degranulation | • zinc ion binding |
Pathways
• Matrix Metalloproteinases (MMPs)
• Extracellular matrix organization
• Neutrophil degranulation
Protein Summary
MMP25 (MT6-MMP) is a 562-amino acid membrane-anchored matrix metalloproteinase with a catalytic domain, a hinge region, and a C-terminal GPI anchor. It is synthesized as a zymogen and activated by furin cleavage. The protein degrades extracellular matrix components such as collagen IV, gelatin, and fibronectin, and activates other MMPs (e.g., pro-MMP2). It is primarily expressed in leukocytes and is implicated in inflammatory diseases and cancer metastasis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MMP25 Knockout HEK293 Cell Line | EDJ-KQ14276 | Human | 64386 | Details Get a Quote |
| MMP25 Knockout HCT 116 Cell Line | EDJ-KQ44307 | Human | 64386 | Details Get a Quote |
| MMP25 Knockout HeLa Cell Line | EDJ-KQ57051 | Human | 64386 | Details Get a Quote |
| MMP25 Knockout A-549 Cell Line | EDJ-KQ65562 | Human | 64386 | Details Get a Quote |
| MMP25 Knockout HAP1 Cell Line | EDC08199 | Human | 64386 | Details Get a Quote |
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