MMP24OS (MMP24 Opposite Strand) Gene: A Non-Coding RNA with Potential Regulatory Roles
Explore the genomic context, expression patterns, and potential implications of MMP24OS, a long non-coding RNA gene located opposite to MMP24.
Gene Information Card
| Symbol | MMP24OS |
|---|---|
| Full Name | MMP24 Opposite Strand |
| Gene Type | Non-coding RNA (lncRNA) |
| Chromosomal Location | 20q11.22 |
| NCBI Gene ID | 100506658 ncbi.nlm.nih.gov/gene/100506658 |
| Ensembl ID | ENSG00000260916 |
| UniProt ID | Not applicable (non-coding) |
| OMIM ID | Not assigned |
| HGNC ID | HGNC:49572 |
| Aliases | MMP24-AS1, MMP24 antisense RNA 1 |
Description
MMP24OS is a long non-coding RNA (lncRNA) gene located on chromosome 20q11.22, positioned opposite to the MMP24 gene (matrix metallopeptidase 24). It is transcribed from the antisense strand and may regulate MMP24 expression or function. The gene is annotated in major genomic databases, but its biological role remains largely unexplored. Expression data suggest tissue-specific patterns, and potential involvement in cancer and neurological conditions has been hypothesized, though evidence is limited.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | Potential dysregulation of lncRNA expression affecting tumor progression | Limited; inferred from lncRNA studies and proximity to MMP24 |
| Neurological disorders | Possible antisense regulation of MMP24, which is involved in synaptic plasticity | Hypothetical; no direct clinical evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 5.2 | Low |
| Testis | 3.1 | Low |
| Lung | 2.0 | Low |
| Liver | 1.5 | Low |
| Kidney | 1.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 2.5 | Low expression |
| A549 | 1.8 | Low expression |
| HepG2 | 1.3 | Low expression |
| K562 | 0.9 | Very low |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs123456 (example) | SNV | 0.01% | Unknown; no functional studies |
Mutation functional classification
Loss of Function (LOF)
No known loss-of-function mutations reported.
Gain of Function (GOF)
No known gain-of-function mutations reported.
Dominant Negative (DN)
Not applicable for non-coding RNA.
View complete mutation data：
Protein Summary
MMP24OS does not encode a protein; it functions as a long non-coding RNA. Its primary transcript may interact with chromatin remodeling complexes or microRNAs to modulate gene expression, particularly of the neighboring MMP24 gene. However, detailed mechanistic studies are lacking.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MMP24OS Knockout HEK293 Cell Line | EDJ-KQ14275 | Human | 101410538 | Details Get a Quote |
| MMP24OS Knockout A-549 Cell Line | EDJ-KQ44304 | Human | 101410538 | Details Get a Quote |
| MMP24OS Knockout HCT 116 Cell Line | EDJ-KQ44305 | Human | 101410538 | Details Get a Quote |
| MMP24OS Knockout HeLa Cell Line | EDJ-KQ44306 | Human | 101410538 | Details Get a Quote |
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