MMP17 Gene (Matrix Metallopeptidase 17)
Membrane-type matrix metalloproteinase involved in extracellular matrix remodeling and cancer progression
Gene Information Card
| Symbol | MMP17 |
|---|---|
| Full Name | Matrix Metallopeptidase 17 |
| Gene Type | protein-coding |
| Chromosomal Location | 12q24.33 |
| NCBI Gene ID | 4326 ncbi.nlm.nih.gov/gene/4326 |
| Ensembl ID | ENSG00000198598 |
| UniProt ID | Q9ULZ9 |
| OMIM ID | 602285 |
| HGNC ID | 7163 |
| Aliases | MT4-MMP, MMP-17, MT-MMP 4 |
Description
MMP17 (Matrix Metallopeptidase 17) encodes a member of the matrix metalloproteinase (MMP) family, specifically a membrane-type MMP (MT4-MMP). This enzyme is anchored to the cell membrane via a glycosylphosphatidylinositol (GPI) anchor and functions in the degradation of extracellular matrix components, cell migration, and invasion. It is implicated in tumor progression, angiogenesis, and inflammatory processes.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various) | Overexpression promotes tumor invasion and metastasis via ECM degradation and activation of signaling pathways | COSMIC, literature |
| Rheumatoid Arthritis | Increased MMP17 expression in synovial tissue contributes to joint destruction | PubMed studies |
| Atherosclerosis | MMP17-mediated ECM remodeling in vascular walls may influence plaque stability | PubMed studies |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 5.2 | Low |
| Heart | 3.8 | Low |
| Kidney | 4.1 | Low |
| Liver | 2.5 | Not detected |
| Lung | 6.7 | Medium |
| Placenta | 8.9 | Medium |
| Spleen | 1.9 | Not detected |
| Testis | 7.3 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 4.5 | Cervical cancer cell line |
| MCF7 | 6.2 | Breast cancer cell line |
| A549 | 5.8 | Lung cancer cell line |
| HepG2 | 2.1 | Hepatocellular carcinoma cell line |
| HT-29 | 7.0 | Colorectal adenocarcinoma cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.01% | Unknown significance |
| c.200C>T | Nonsense | <0.01% | Predicted loss of function |
| c.350G>A | Missense | <0.01% | Unknown significance |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations (e.g., c.200C>T) are predicted to cause premature truncation and loss of catalytic activity.
Gain of Function (GOF)
Not well documented; overexpression in tumors may act as a gain-of-function mechanism.
Dominant Negative (DN)
No evidence for dominant-negative effects in current literature.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Matrix Metalloproteinases (MMPs) pathway
• Extracellular matrix organization
• Degradation of the extracellular matrix
Protein Summary
MMP17 (MT4-MMP) is a 578-amino acid membrane-anchored matrix metalloproteinase with a catalytic domain, a hinge region, and a C-terminal GPI anchor. It is synthesized as a zymogen and activated by proteolytic cleavage. The enzyme degrades components of the extracellular matrix such as gelatin, fibronectin, and laminin, and activates pro-MMP2. It is expressed in various tissues and overexpressed in several cancers, contributing to tumor invasion and metastasis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MMP17 Knockout HEK293 Cell Line | EDJ-KQ5229 | Human | 4326 | Details Get a Quote |
| MMP17 Knockout A-549 Cell Line | EDJ-KQ27016 | Human | 4326 | Details Get a Quote |
| MMP17 Knockout HCT 116 Cell Line | EDJ-KQ28253 | Human | 4326 | Details Get a Quote |
| MMP17 Knockout HeLa Cell Line | EDJ-KQ28254 | Human | 4326 | Details Get a Quote |
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