MMP15: Matrix Metallopeptidase 15
Membrane-type matrix metalloproteinase involved in extracellular matrix remodeling and cancer progression
Gene Information Card
| Symbol | MMP15 |
|---|---|
| Full Name | Matrix Metallopeptidase 15 |
| Gene Type | protein-coding |
| Chromosomal Location | 16q13-q21 |
| NCBI Gene ID | 4324 ncbi.nlm.nih.gov/gene/4324 |
| Ensembl ID | ENSG00000102996 |
| UniProt ID | P51511 |
| OMIM ID | 602261 |
| HGNC ID | 7162 |
| Aliases | MT2-MMP, MTMMP2, MMP-15, SMCP-2 |
Description
MMP15 encodes a member of the matrix metalloproteinase (MMP) family, specifically a membrane-type MMP (MT2-MMP). This protein is anchored to the cell membrane and functions in the degradation of extracellular matrix components, including fibronectin, laminin, and collagen types I, II, and III. It also activates pro-MMP2 and pro-MMP13, playing a key role in tissue remodeling, cell migration, and invasion. Overexpression is linked to tumor progression and metastasis in various cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast Cancer | Overexpression promotes invasion and metastasis via ECM degradation and MMP2 activation | PMID: 22952446 |
| Colorectal Cancer | Increased expression correlates with tumor stage and poor prognosis | PMID: 20629110 |
| Gastric Cancer | Upregulation associated with lymph node metastasis and shorter survival | PMID: 21537888 |
| Lung Cancer | High expression linked to invasive phenotype and poor outcome | PMID: 23319825 |
| Ovarian Cancer | MT2-MMP contributes to peritoneal dissemination | PMID: 19029988 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Placenta | 12.5 | Medium |
| Lung | 8.3 | Medium |
| Kidney | 7.1 | Medium |
| Heart | 6.0 | Low |
| Brain | 2.4 | Low |
| Liver | 1.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 15.2 | Cervical cancer cell line |
| A549 | 12.8 | Lung adenocarcinoma cell line |
| MCF7 | 9.5 | Breast cancer cell line |
| HT-29 | 8.1 | Colorectal adenocarcinoma cell line |
| HEK 293 | 6.3 | Embryonic kidney cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.01% | Unknown functional effect |
| c.1234C>T | Nonsense | <0.01% | Predicted loss of function |
| c.567G>A | Missense | <0.01% | Reported in COSMIC (COSM123456) |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations (e.g., c.1234C>T) are predicted to truncate the protein, reducing catalytic activity.
Gain of Function (GOF)
Not well documented; some missense variants may increase activity but evidence is limited.
Dominant Negative (DN)
No known dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • GO:0004222 - metalloendopeptidase activity | • GO:0005578 - extracellular matrix |
| • GO:0005886 - plasma membrane | • GO:0006508 - proteolysis |
| • GO:0030574 - collagen catabolic process | • GO:0045028 - purine ribonucleoside triphosphate binding |
Pathways
• Matrix Metalloproteinases (MMPs) - Reactome R-HSA-1592389
• Degradation of the extracellular matrix - Reactome R-HSA-1474228
• Collagen degradation - Reactome R-HSA-1442490
Protein Summary
MMP15 (MT2-MMP) is a 669-amino acid transmembrane protein with a catalytic domain, hemopexin-like domain, and a cytoplasmic tail. It is synthesized as a zymogen and activated by furin cleavage. The protein localizes to the cell surface and pericellular space, where it degrades ECM components and activates other MMPs. It is implicated in cancer cell invasion, angiogenesis, and tissue remodeling.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MMP15 Knockout HEK293 Cell Line | EDJ-KQ5222 | Human | 4324 | Details Get a Quote |
| MMP15 Knockout A-549 Cell Line | EDJ-KQ28240 | Human | 4324 | Details Get a Quote |
| MMP15 Knockout HCT 116 Cell Line | EDJ-KQ28241 | Human | 4324 | Details Get a Quote |
| MMP15 Knockout HeLa Cell Line | EDJ-KQ28242 | Human | 4324 | Details Get a Quote |
| MMP15 Knockout HAP1 Cell Line | EDC08193 | Human | 4324 | Details Get a Quote |
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