MMP14 (Matrix Metallopeptidase 14)
Membrane-type matrix metalloproteinase 1 (MT1-MMP) – key regulator of extracellular matrix remodeling, cell migration, and invasion.
Gene Information Card
| Symbol | MMP14 |
|---|---|
| Full Name | Matrix Metallopeptidase 14 (membrane-inserted) |
| Gene Type | Protein coding |
| Chromosomal Location | 14q11.2 |
| NCBI Gene ID | 4323 ncbi.nlm.nih.gov/gene/4323 |
| Ensembl ID | ENSG00000157227 |
| UniProt ID | P50281 |
| OMIM ID | 600754 |
| HGNC ID | 7160 |
| Aliases | MT1-MMP, MMP-14, MT-MMP 1 |
Description
MMP14 encodes a membrane-type matrix metalloproteinase (MT1-MMP) that is anchored to the cell surface. It degrades extracellular matrix components (e.g., collagen I, III, fibronectin) and activates pro-MMP2. MMP14 is essential for tissue remodeling, cell migration, angiogenesis, and is implicated in cancer invasion and metastasis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (multiple types) | Overexpression promotes ECM degradation, invasion, and metastasis via activation of MMP2 and cleavage of collagen barriers. | COSMIC, ClinVar, literature |
| Rheumatoid arthritis | Elevated MMP14 in synovial fibroblasts contributes to cartilage destruction. | OMIM, literature |
| Atherosclerosis | MMP14 expressed in macrophages and smooth muscle cells promotes plaque instability. | NCBI, literature |
| Wound healing disorders | Dysregulated MMP14 impairs proper ECM remodeling and re-epithelialization. | UniProt, literature |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.8 | Medium |
| Breast | 9.5 | Medium |
| Colon | 8.2 | Medium |
| Skin | 7.1 | Medium |
| Liver | 6.3 | Low |
| Brain | 2.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa (cervical) | 15.2 | High expression |
| A549 (lung) | 13.4 | High expression |
| MCF7 (breast) | 10.1 | Medium expression |
| HepG2 (liver) | 5.8 | Low expression |
| U87MG (glioblastoma) | 11.7 | High expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | <0.01% | Potential loss of start codon; functional impact unknown |
| c.632C>T (p.Thr211Ile) | Missense | <0.01% | Reported in COSMIC; uncertain significance |
| c.1045G>A (p.Gly349Arg) | Missense | <0.01% | COSMIC; possible gain-of-function in cancer |
| c.1282G>A (p.Gly428Arg) | Missense | <0.01% | ClinVar; uncertain significance |
Mutation functional classification
Loss of Function (LOF)
Rare missense variants near catalytic domain may impair proteolytic activity; not well characterized.
Gain of Function (GOF)
Some COSMIC-reported missense variants (e.g., p.Gly349Arg) are suspected to enhance activity in cancer cells.
Dominant Negative (DN)
Not reported for MMP14.
View complete mutation data：
Gene Ontology (GO)
| • metalloendopeptidase activity (GO:0004222) | • protein binding (GO:0005515) |
| • plasma membrane (GO:0005886) | • collagen catabolic process (GO:0030574) |
| • extracellular structure organization (GO:0043062) | • integral component of membrane (GO:0016021) |
Pathways
• Matrix metalloproteinase pathway (Reactome: R-HSA-1592389)
• Degradation of extracellular matrix (Reactome: R-HSA-1474228)
• Activation of MMP2 by MT1-MMP (Reactome: R-HSA-1592390)
• Collagen degradation (Reactome: R-HSA-1442490)
Protein Summary
MMP14 (MT1-MMP) is a 582-amino acid transmembrane metalloproteinase with a catalytic domain, hemopexin-like domain, and a cytoplasmic tail. It localizes to the cell surface and pericellular space, where it degrades collagen I, III, fibronectin, and activates pro-MMP2. It is a key driver of cell invasion, angiogenesis, and tumor metastasis. Its expression is upregulated in many cancers and inflammatory diseases.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MMP14 Knockout HEK293 Cell Line | EDJ-KQ1484 | Human | 4323 | Details Get a Quote |
| MMP14 Knockout A-549 Cell Line | EDJ-KQ21072 | Human | 4323 | Details Get a Quote |
| MMP14 Knockout HCT 116 Cell Line | EDJ-KQ21073 | Human | 4323 | Details Get a Quote |
| MMP14 Knockout HeLa Cell Line | EDJ-KQ19739 | Human | 4323 | Details Get a Quote |
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