MMP10 Gene (Matrix Metallopeptidase 10)
Stromelysin-2: A Key Regulator of Extracellular Matrix Remodeling
Gene Information Card
| Symbol | MMP10 |
|---|---|
| Full Name | Matrix Metallopeptidase 10 |
| Gene Type | Protein coding |
| Chromosomal Location | 11q22.2 |
| NCBI Gene ID | 4319 ncbi.nlm.nih.gov/gene/4319 |
| Ensembl ID | ENSG00000166670 |
| UniProt ID | P09238 |
| OMIM ID | 185260 |
| HGNC ID | 7157 |
| Aliases | SL-2, STMY2, stromelysin-2 |
Description
MMP10 (matrix metallopeptidase 10) encodes a member of the matrix metalloproteinase (MMP) family, specifically stromelysin-2. This secreted endopeptidase degrades various extracellular matrix components, including fibronectin, laminin, and proteoglycans. It also activates other MMPs, such as pro-MMP1 and pro-MMP8, playing a critical role in tissue remodeling, wound healing, and inflammation. Dysregulation of MMP10 is implicated in cancer progression, arthritis, and cardiovascular diseases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (e.g., colorectal, lung, breast) | Overexpression promotes tumor invasion and metastasis via ECM degradation and MMP activation | COSMIC, NCBI |
| Osteoarthritis | Increased MMP10 activity contributes to cartilage degradation | NCBI, OMIM |
| Chronic wounds | Altered expression impairs wound healing | NCBI |
| Atherosclerosis | MMP10-mediated ECM remodeling in vascular walls | NCBI |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.3 | Medium |
| Skin | 8.7 | Medium |
| Colon | 6.5 | Low |
| Breast | 4.2 | Low |
| Liver | 2.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 (lung carcinoma) | 15.6 | High expression |
| HT-29 (colorectal adenocarcinoma) | 9.8 | Medium expression |
| MCF7 (breast adenocarcinoma) | 3.4 | Low expression |
| HepG2 (hepatocellular carcinoma) | 1.2 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | <0.01% | Potential loss of start codon |
| c.214G>A (p.Gly72Ser) | Missense | <0.01% | Unknown |
| c.445C>T (p.Arg149Trp) | Missense | <0.01% | Unknown |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • metalloendopeptidase activity (GO:0004222) | • extracellular matrix (GO:0005578) |
| • proteolysis (GO:0006508) | • collagen catabolic process (GO:0030574) |
| • extracellular structure organization (GO:0043062) |
Pathways
• Matrix metalloproteinases (MMPs) pathway
• Degradation of the extracellular matrix
• Collagen degradation
Protein Summary
MMP10 (stromelysin-2) is a 54 kDa secreted protein that degrades fibronectin, laminin, and proteoglycans. It is synthesized as a zymogen and activated by proteolytic cleavage. The protein contains a signal peptide, a prodomain, a catalytic domain with a zinc-binding site, and a hemopexin-like domain. It is involved in ECM remodeling, wound healing, and inflammation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MMP10 Knockout HEK293 Cell Line | EDJ-KQ4450 | Human | 4319 | Details Get a Quote |
| MMP10 Knockout HeLa Cell Line | EDJ-KQ53886 | Human | 4319 | Details Get a Quote |
| MMP10 Knockout A-549 Cell Line | EDJ-KQ62377 | Human | 4319 | Details Get a Quote |
| MMP10 Knockout HCT 116 Cell Line | EDJ-KQ70847 | Human | 4319 | Details Get a Quote |
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