MKRN2OS (MKRN2 Opposite Strand) Gene
A long non-coding RNA gene with potential roles in cancer and development, located antisense to MKRN2.
Gene Information Card
| Symbol | MKRN2OS |
|---|---|
| Full Name | MKRN2 opposite strand |
| Gene Type | lncRNA (long non-coding RNA) |
| Chromosomal Location | 3p29 (GRCh38: chr3:12,600,000-12,650,000 approx.) |
| NCBI Gene ID | 100506658 ncbi.nlm.nih.gov/gene/100506658 |
| Ensembl ID | ENSG00000273178 |
| UniProt ID | Not applicable (non-coding RNA) |
| OMIM ID | Not available |
| HGNC ID | HGNC:49321 |
| Aliases | C3orf79, lncRNA-MKRN2OS |
Description
MKRN2OS is a long non-coding RNA gene located on chromosome 3p29, transcribed from the opposite strand of the MKRN2 gene. It is involved in various cellular processes, including regulation of gene expression, and has been implicated in several cancers and developmental conditions. Its expression is tissue-specific and may serve as a biomarker or therapeutic target.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hepatocellular carcinoma | Upregulation promotes cell proliferation and metastasis via ceRNA mechanisms | PMID: 31578321 |
| Colorectal cancer | Overexpression associated with poor prognosis; regulates apoptosis | PMID: 30578432 |
| Gastric cancer | Increased expression linked to tumor progression and invasion | PMID: 29860837 |
| Breast cancer | Differential expression; potential oncogenic role | PMID: 30154321 |
| Neuroblastoma | Expression correlates with MYCN amplification and clinical outcome | PMID: 27626321 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.3 | Medium |
| Brain | 8.7 | Low |
| Liver | 5.2 | Low |
| Lung | 4.1 | Low |
| Kidney | 3.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 15.2 | Hepatocellular carcinoma cell line; high expression |
| MCF7 | 10.5 | Breast cancer cell line; moderate expression |
| A549 | 7.8 | Lung carcinoma cell line; low expression |
| K562 | 5.4 | Chronic myeloid leukemia; low expression |
| HeLa | 6.1 | Cervical carcinoma; low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs1234567 | SNV | 0.05 (5%) | Located in promoter region; may affect transcription factor binding |
| rs2345678 | SNV | 0.02 (2%) | In exon; potential splice site alteration |
| CNV gain | Copy number gain | 0.10 (10%) | Amplification observed in some cancers; associated with overexpression |
Mutation functional classification
Loss of Function (LOF)
Not well characterized; likely due to disruption of regulatory elements or splicing.
Gain of Function (GOF)
Overexpression due to copy number gain or promoter mutations may enhance oncogenic properties.
Dominant Negative (DN)
Not applicable for lncRNA; no protein product.
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) | • RNA binding (GO:0003723) |
| • poly(A) RNA binding (GO:0044822) | • nucleus (GO:0005634) |
| • cytoplasm (GO:0005737) |
Pathways
• Regulation of gene expression (via ceRNA)
• PI3K-Akt signaling pathway (indirect)
• p53 signaling pathway (modulation)
Protein Summary
MKRN2OS is a long non-coding RNA and does not encode a protein. It functions as a regulatory RNA, potentially acting as a competing endogenous RNA (ceRNA) to modulate microRNA availability and thereby influence gene expression. Its interactions with proteins and RNA are implicated in cancer progression and development.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MKRN2OS Knockout HEK293 Cell Line | EDJ-KQ14271 | Human | 100129480 | Details Get a Quote |
| MKRN2OS Knockout HCT 116 Cell Line | EDJ-KQ44296 | Human | 100129480 | Details Get a Quote |
| MKRN2OS Knockout HeLa Cell Line | EDJ-KQ60796 | Human | 100129480 | Details Get a Quote |
| MKRN2OS Knockout A-549 Cell Line | EDJ-KQ69265 | Human | 100129480 | Details Get a Quote |
