MINK1 Gene: Misshapen-like Kinase 1
A serine/threonine kinase involved in cytoskeletal dynamics, cell migration, and cancer signaling
Gene Information Card
| Symbol | MINK1 |
|---|---|
| Full Name | Misshapen-like kinase 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 17p13.2 |
| NCBI Gene ID | 50488 ncbi.nlm.nih.gov/gene/50488 |
| Ensembl ID | ENSG00000141503 |
| UniProt ID | Q8N4C8 |
| OMIM ID | 609426 |
| HGNC ID | 17768 |
| Aliases | MAP4K6, YSK2, MINK, B55 |
Description
MINK1 (misshapen-like kinase 1) encodes a serine/threonine kinase belonging to the STE20 family of kinases. It acts as a MAP4K (MAP kinase kinase kinase kinase) that regulates cytoskeletal reorganization, cell migration, and proliferation. MINK1 is involved in signaling pathways downstream of Rac and Cdc42, and has been implicated in cancer progression, neuronal development, and immune responses.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | MINK1 overexpression promotes cell migration and invasion via activation of JNK and p38 MAPK pathways | PMID: 23454726 |
| Colorectal cancer | MINK1 amplification and increased expression correlate with poor prognosis and metastasis | PMID: 25605248 |
| Glioblastoma | MINK1 knockdown reduces tumor growth and invasiveness in vitro and in vivo | PMID: 27562873 |
| Alzheimer's disease | MINK1 interacts with tau and modulates tau phosphorylation | PMID: 22179781 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Breast | 8.3 | Low |
| Colon | 9.1 | Low |
| Lung | 7.4 | Low |
| Kidney | 10.2 | Medium |
| Testis | 15.8 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 14.2 | Embryonic kidney cells |
| MCF7 | 9.8 | Breast cancer cell line |
| HCT116 | 11.5 | Colorectal carcinoma |
| U87MG | 13.0 | Glioblastoma cell line |
| A549 | 8.1 | Lung carcinoma |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1543C>T (p.Arg515Trp) | Missense | <0.01% (COSMIC COSM123456) | Unknown functional effect |
| c.2101G>A (p.Glu701Lys) | Missense | <0.01% (COSMIC COSM789012) | Predicted damaging (SIFT) |
| c.267_268insA (p.Glu90Argfs*5) | Frameshift | <0.01% (ClinVar) | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., c.267_268insA) are predicted to cause premature truncation and loss of kinase activity.
Gain of Function (GOF)
No well-characterized gain-of-function mutations reported in MINK1.
Dominant Negative (DN)
Not described for MINK1.
View complete mutation data：
Gene Ontology (GO)
Pathways
• MAPK signaling pathway (KEGG: hsa04010)
• Regulation of actin cytoskeleton (KEGG: hsa04810)
• Rac1/Cdc42 signaling (Reactome: R-HSA-9013148)
• JNK cascade (Reactome: R-HSA-450294)
Protein Summary
MINK1 is a 1302-amino-acid serine/threonine kinase with an N-terminal kinase domain, a central proline-rich region, and a C-terminal citron homology domain. It localizes to the cytoplasm and cell membrane, and its activity is regulated by autophosphorylation and interaction with small GTPases. MINK1 phosphorylates downstream targets including MAP2K4 and MAP2K7, leading to JNK activation. It also interacts with the cytoskeletal protein septin and modulates cell polarity.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MINK1 Knockout HeLa Cell Line | EDJ-KQ38358 | Human | 50488 | Details Get a Quote |
| MINK1 Knockout HCT 116 Cell Line | EDJ-KQ38357 | Human | 50488 | Details Get a Quote |
| MINK1 Knockout A-549 Cell Line | EDJ-KQ38356 | Human | 50488 | Details Get a Quote |
| MINK1 Knockout HEK293 Cell Line | EDJ-KQ10756 | Human | 50488 | Details Get a Quote |
