MID1IP1
MID1 Interacting Protein 1
Gene Information Card
| Symbol | MID1IP1 |
|---|---|
| Full Name | MID1 Interacting Protein 1 |
| Gene Type | protein-coding |
| Chromosomal Location | Xp11.4 |
| NCBI Gene ID | 58526 ncbi.nlm.nih.gov/gene/58526 |
| Ensembl ID | ENSG00000147180 |
| UniProt ID | Q9NPA3 |
| OMIM ID | 300982 |
| HGNC ID | 26034 |
| Aliases | MGC8730, STRA7, MIR, MID1IP1 |
Description
MID1IP1 encodes a protein that interacts with MID1, a component of the ubiquitin ligase complex. The protein is involved in microtubule dynamics and may play a role in cell cycle regulation. It is expressed in multiple tissues and has been implicated in certain cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Altered expression of MID1IP1 may affect cell proliferation and migration; potential oncogenic role | COSMIC database reports mutations in breast cancer samples |
| Lung cancer | Overexpression observed in lung adenocarcinoma; may promote tumor growth | COSMIC and literature evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 15.2 | Medium |
| Thyroid | 10.8 | Medium |
| Adrenal gland | 9.5 | Low |
| Brain | 6.3 | Low |
| Liver | 4.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 12.5 | Embryonic kidney cell line |
| HeLa | 8.7 | Cervical cancer cell line |
| A549 | 7.3 | Lung carcinoma cell line |
| MCF7 | 6.9 | Breast cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.200C>T (p.Pro67Leu) | Missense | <0.1% | Unknown functional impact |
| c.341G>A (p.Arg114Gln) | Missense | <0.1% | Reported in COSMIC; uncertain significance |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in major databases.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • microtubule binding | • protein binding |
| • ubiquitin ligase complex | • cytoplasm |
| • nucleus |
Pathways
• Ubiquitin mediated proteolysis
• MID1 ubiquitin ligase pathway
Protein Summary
The MID1IP1 protein is 336 amino acids long and contains a coiled-coil domain. It interacts with MID1 and localizes to microtubules. It may regulate cell cycle progression and is implicated in cancer cell proliferation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MID1IP1 Knockout HEK293 Cell Line | EDJ-KQ11147 | Human | 58526 | Details Get a Quote |
| MID1IP1 Knockout A-549 Cell Line | EDJ-KQ40392 | Human | 58526 | Details Get a Quote |
| MID1IP1 Knockout HCT 116 Cell Line | EDJ-KQ40394 | Human | 58526 | Details Get a Quote |
| MID1IP1 Knockout HeLa Cell Line | EDJ-KQ40395 | Human | 58526 | Details Get a Quote |
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