MICOS10-NBL1: A Read-Through Transcript with Emerging Roles in Cancer and Development
Explore the genomic structure, expression, and clinical significance of the MICOS10-NBL1 fusion gene, a read-through transcript at the 1p36 locus.
Gene Information Card
| Symbol | MICOS10-NBL1 |
|---|---|
| Full Name | MICOS10-NBL1 readthrough |
| Gene Type | Read-through transcript (protein-coding) |
| Chromosomal Location | 1p36.33-p36.32 |
| NCBI Gene ID | 100287596 ncbi.nlm.nih.gov/gene/100287596 |
| Ensembl ID | ENSG00000269335 |
| UniProt ID | Not available (no protein product annotated) |
| OMIM ID | Not available |
| HGNC ID | HGNC:48829 |
| Aliases | C1orf151-NBL1, NBL1-C1orf151 |
Description
MICOS10-NBL1 is a naturally occurring read-through transcript that spans the adjacent MICOS10 (formerly C1orf151) and NBL1 (Neuroblastoma Suppressor of Tumorigenicity 1) genes on chromosome 1p36. This locus is frequently deleted in neuroblastoma and other cancers, and the read-through transcript may produce a chimeric mRNA that could influence gene regulation or protein function. The gene is listed in NCBI and HGNC, but no protein product has been characterized to date.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Neuroblastoma | The 1p36 region, including NBL1, is commonly deleted in neuroblastoma; MICOS10-NBL1 read-through may be disrupted by genomic deletions, potentially affecting NBL1 expression. | ClinVar, COSMIC |
| Various cancers | Loss of heterozygosity at 1p36 is observed in multiple tumor types; the read-through transcript may be involved in tumor suppression via NBL1. | COSMIC, NCBI |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | Not available | Not determined |
| Lung | Not available | Not determined |
| Liver | Not available | Not determined |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | Not available | No data |
| HEK293 | Not available | No data |
| SH-SY5Y (neuroblastoma) | Not available | Potential relevance due to 1p36 deletion |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No specific variants curated | Not applicable | Not applicable | No clinical significance reported |
Mutation functional classification
Loss of Function (LOF)
No functional data available; deletions of the 1p36 region may lead to loss of NBL1 tumor suppressor activity.
Gain of Function (GOF)
No evidence for gain-of-function mutations.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • No GO terms assigned to MICOS10-NBL1; NBL1 is involved in BMP signaling pathway (). (GO:0030509) |
Pathways
• BMP signaling pathway (via NBL1)
Protein Summary
MICOS10-NBL1 is a read-through transcript that produces a chimeric mRNA potentially encoding a fusion protein of MICOS10 and NBL1. However, no protein product has been experimentally validated. The NBL1 portion is a secreted BMP antagonist, while MICOS10 is a mitochondrial inner membrane protein. The biological significance of the read-through transcript remains unclear.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MICOS10-NBL1 Knockout HEK293 Cell Line | EDJ-KQ52503 | Human | 100532736 | Details Get a Quote |
| MICOS10-NBL1 Knockout HeLa Cell Line | EDJ-KQ60966 | Human | 100532736 | Details Get a Quote |
| MICOS10-NBL1 Knockout A-549 Cell Line | EDJ-KQ69441 | Human | 100532736 | Details Get a Quote |
| MICOS10-NBL1 Knockout HCT 116 Cell Line | EDJ-KQ77792 | Human | 100532736 | Details Get a Quote |
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