MGAT4C
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C
Gene Information Card
| Symbol | MGAT4C |
|---|---|
| Full Name | Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C |
| Gene Type | protein-coding |
| Chromosomal Location | 12q21.31 |
| NCBI Gene ID | 25834 ncbi.nlm.nih.gov/gene/25834 |
| Ensembl ID | ENSG00000135446 |
| UniProt ID | Q9UJ53 |
| OMIM ID | 604623 |
| HGNC ID | 7048 |
| Aliases | GNT-IVC, GNT-4C, GnT-IVc |
Description
MGAT4C encodes a member of the N-acetylglucosaminyltransferase family, specifically GnT-IVc, which catalyzes the transfer of N-acetylglucosamine to mannose residues on N-glycans, forming tri- and tetra-antennary structures. This enzyme is involved in the biosynthesis of complex N-glycans and plays a role in cell adhesion, migration, and signaling. Alternative splicing results in multiple transcript variants.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal cancer | Altered N-glycan branching may promote metastasis | COSMIC, literature |
| Hepatocellular carcinoma | Upregulation of MGAT4C correlates with poor prognosis | PubMed, TCGA |
| Breast cancer | Expression changes linked to tumor progression | COSMIC, literature |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.3 | Medium |
| Kidney | 8.7 | Low |
| Colon | 6.5 | Low |
| Breast | 4.2 | Low |
| Lung | 3.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 15.1 | Hepatocellular carcinoma cell line |
| HT-29 | 7.8 | Colorectal adenocarcinoma cell line |
| MCF7 | 5.3 | Breast cancer cell line |
| A549 | 2.9 | Lung carcinoma cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T | Missense | <0.01% | p.Arg412Cys, unknown significance |
| c.567_568insA | Frameshift | <0.01% | Predicted loss of function |
| c.890G>A | Synonymous | 0.02% | No effect on protein |
Mutation functional classification
Loss of Function (LOF)
Frameshift insertions likely lead to truncated, non-functional protein.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
| • N-acetylglucosaminyltransferase activity | • Golgi membrane |
| • protein glycosylation | • transferase activity |
| • transferring glycosyl groups |
Pathways
• N-Glycan biosynthesis
• Metabolism of proteins
• Post-translational protein modification
Protein Summary
The MGAT4C protein (UniProt Q9UJ53) is a type II transmembrane glycosyltransferase localized to the Golgi apparatus. It contains a short N-terminal cytoplasmic domain, a transmembrane domain, and a large C-terminal catalytic domain facing the Golgi lumen. The enzyme adds a beta-1,4-linked N-acetylglucosamine to the alpha-1,3-mannose arm of the core N-glycan, generating tri- and tetra-antennary structures critical for glycoprotein function.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MGAT4C Knockout HEK293 Cell Line | EDJ-KQ8256 | Human | 25834 | Details Get a Quote |
| MGAT4C Knockout HeLa Cell Line | EDJ-KQ55827 | Human | 25834 | Details Get a Quote |
| MGAT4C Knockout A-549 Cell Line | EDJ-KQ64319 | Human | 25834 | Details Get a Quote |
| MGAT4C Knockout HCT 116 Cell Line | EDJ-KQ72772 | Human | 25834 | Details Get a Quote |
