MGAM2: Maltase-Glucoamylase 2 (Putative)
A putative alpha-glucosidase gene involved in starch digestion and carbohydrate metabolism.
Gene Information Card
| Symbol | MGAM2 |
|---|---|
| Full Name | Maltase-Glucoamylase 2 (Putative) |
| Gene Type | Protein-coding |
| Chromosomal Location | 7q34 |
| NCBI Gene ID | 100129924 ncbi.nlm.nih.gov/gene/100129924 |
| Ensembl ID | ENSG00000205560 |
| UniProt ID | Q2M2I8 |
| OMIM ID | None |
| HGNC ID | 37299 |
| Aliases | MGAM2, MGC119173, MGC119174 |
Description
MGAM2 (Maltase-Glucoamylase 2) is a putative protein-coding gene located on chromosome 7q34. It is predicted to encode an alpha-glucosidase enzyme involved in the hydrolysis of terminal alpha-1,4-linked glucose residues from oligosaccharides and starch, contributing to carbohydrate digestion. The gene is part of the glycosyl hydrolase family 31 and is closely related to MGAM (maltase-glucoamylase). Expression data suggest low to moderate levels in specific tissues, but its functional significance and disease associations remain under investigation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| None reported | No direct disease association documented in ClinVar or OMIM. | No evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Small Intestine | 0.5 | Low |
| Colon | 0.3 | Low |
| Liver | 0.1 | Not detected |
| Pancreas | 0.2 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Caco-2 | 0.4 | Colorectal adenocarcinoma cell line |
| HT-29 | 0.3 | Colorectal adenocarcinoma cell line |
| HepG2 | 0.1 | Hepatocellular carcinoma cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No documented loss-of-function variants.
Gain of Function (GOF)
No documented gain-of-function variants.
Dominant Negative (DN)
No documented dominant-negative variants.
View complete mutation data：
Gene Ontology (GO)
| • hydrolase activity, hydrolyzing O-glycosyl compounds (GO:0004553) | • carbohydrate metabolic process (GO:0005975) |
| • hydrolase activity, acting on glycosyl bonds (GO:0016798) |
Pathways
• ['Starch and sucrose metabolism (KEGG: hsa00500)']
• ['Carbohydrate digestion and absorption (KEGG: hsa04973)']
Protein Summary
The MGAM2 protein is a putative alpha-glucosidase belonging to glycosyl hydrolase family 31. It is predicted to catalyze the hydrolysis of terminal alpha-1,4-linked glucose residues from starch and oligosaccharides, playing a role in carbohydrate digestion. The protein sequence shares homology with maltase-glucoamylase (MGAM), but its exact enzymatic activity and physiological relevance require further experimental validation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MGAM2 Knockout HEK293 Cell Line | EDJ-KQ11233 | Human | 93432 | Details Get a Quote |
| MGAM2 Knockout HeLa Cell Line | EDJ-KQ57864 | Human | 93432 | Details Get a Quote |
| MGAM2 Knockout A-549 Cell Line | EDJ-KQ66360 | Human | 93432 | Details Get a Quote |
| MGAM2 Knockout HCT 116 Cell Line | EDJ-KQ74783 | Human | 93432 | Details Get a Quote |
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