MGA Gene - MAX Dimerization Protein
Transcriptional Regulator and Tumor Suppressor
Gene Information Card
| Symbol | MGA |
|---|---|
| Full Name | MAX dimerization protein |
| Gene Type | Protein coding |
| Chromosomal Location | 15q14 |
| NCBI Gene ID | 23269 ncbi.nlm.nih.gov/gene/23269 |
| Ensembl ID | ENSG00000137868 |
| UniProt ID | Q8IWI9 |
| OMIM ID | 616197 |
| HGNC ID | 14010 |
| Aliases | MXD5, MAD5, bHLHc35 |
Description
MGA (MAX dimerization protein) encodes a basic helix-loop-helix leucine zipper (bHLHZ) transcription factor that heterodimerizes with MAX to repress transcription of MYC target genes. It functions as a tumor suppressor by regulating cell proliferation and differentiation. The gene is located on chromosome 15q14 and is associated with various cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Lung cancer | Loss of MGA expression leads to derepression of MYC target genes, promoting proliferation | COSMIC, ClinVar |
| Colorectal cancer | Inactivating mutations and deletions of MGA contribute to tumorigenesis | COSMIC, ClinVar |
| Breast cancer | Reduced MGA expression correlates with poor prognosis | NCBI, PubMed |
| Pancreatic cancer | MGA mutations identified in tumor samples | COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.2 | Low |
| Lung | 6.1 | Low |
| Colon | 5.4 | Low |
| Breast | 4.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 (lung) | 7.3 | Low |
| HCT116 (colon) | 6.9 | Low |
| MCF7 (breast) | 5.2 | Low |
| HEK293 (embryonic kidney) | 9.1 | Low |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412*) | Nonsense | <1% | Loss of function |
| c.567_568del (p.Glu190fs) | Frameshift | <1% | Loss of function |
| c.2345G>A (p.Arg782Gln) | Missense | <1% | Unknown |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations truncate the protein, impairing DNA binding and transcriptional repression.
Gain of Function (GOF)
No evidence of gain-of-function mutations in MGA.
Dominant Negative (DN)
No evidence of dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
Pathways
• MYC pathway (repression of MYC target genes)
• MAX network
Protein Summary
MGA is a 2,963-amino acid protein containing a bHLHZip domain that mediates dimerization with MAX. It binds to E-box DNA sequences to repress transcription of MYC-responsive genes. The protein is predominantly nuclear and plays a critical role in cell cycle control and differentiation. Loss of MGA function is implicated in multiple cancers.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MGAT1 Knockout HEK293 Cell Line | EDJ-KQ1872 | Human | 4245 | Details Get a Quote |
| MGAT2 Knockout HEK293 Cell Line | EDJ-KQ2303 | Human | 4247 | Details Get a Quote |
| MGA Knockout HEK293 Cell Line | EDJ-KQ2423 | Human | 23269 | Details Get a Quote |
| MGAT5 Knockout HEK293 Cell Line | EDJ-KQ3012 | Human | 4249 | Details Get a Quote |
| MGAT3 Knockout HEK293 Cell Line | EDJ-KQ5207 | Human | 4248 | Details Get a Quote |
| MGAM Knockout HEK293 Cell Line | EDJ-KQ6420 | Human | 8972 | Details Get a Quote |
| MGAT4B Knockout HEK293 Cell Line | EDJ-KQ7362 | Human | 11282 | Details Get a Quote |
| MGAT4A Knockout HEK293 Cell Line | EDJ-KQ7369 | Human | 11320 | Details Get a Quote |
| MGAT4C Knockout HEK293 Cell Line | EDJ-KQ8256 | Human | 25834 | Details Get a Quote |
| MGARP Knockout HEK293 Cell Line | EDJ-KQ10177 | Human | 84709 | Details Get a Quote |
| MGAT5B Knockout HEK293 Cell Line | EDJ-KQ10487 | Human | 146664 | Details Get a Quote |
| MGAM2 Knockout HEK293 Cell Line | EDJ-KQ11233 | Human | 93432 | Details Get a Quote |
| MGAT4D Knockout HEK293 Cell Line | EDJ-KQ11418 | Human | 152586 | Details Get a Quote |
| MGA Knockout A-549 Cell Line | EDJ-KQ22931 | Human | 23269 | Details Get a Quote |
| MGA Knockout HCT 116 Cell Line | EDJ-KQ22932 | Human | 23269 | Details Get a Quote |
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