METTL2B
Methyltransferase Like 2B
Gene Information Card
| Symbol | METTL2B |
|---|---|
| Full Name | Methyltransferase Like 2B |
| Gene Type | Protein coding |
| Chromosomal Location | 7q22.1 |
| NCBI Gene ID | 55798 ncbi.nlm.nih.gov/gene/55798 |
| Ensembl ID | ENSG00000106344 |
| UniProt ID | Q6P1N9 |
| OMIM ID | 616830 |
| HGNC ID | 24865 |
| Aliases | Mettl2, METTL2, FLJ22662 |
Description
METTL2B encodes a methyltransferase-like protein that catalyzes the N6-methyladenosine (m6A) modification of RNA, specifically targeting tRNAs and other non-coding RNAs. This modification plays a role in RNA stability, splicing, and translation. The gene is ubiquitously expressed with highest levels in testis and brain.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various) | Altered m6A methylation affecting oncogene/tumor suppressor expression | COSMIC database reports somatic mutations in multiple cancer types |
| Intellectual disability (candidate) | Potential loss-of-function affecting RNA metabolism | ClinVar lists uncertain significance variants |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.3 | Low |
| Liver | 6.1 | Low |
| Heart | 5.4 | Low |
| Kidney | 4.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 10.2 | Embryonic kidney cells |
| HeLa | 8.7 | Cervical cancer cells |
| K562 | 7.1 | Leukemia cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1015C>T (p.Arg339Trp) | Missense | 0.01% (gnomAD) | Unknown functional impact |
| c.1246G>A (p.Gly416Arg) | Missense | 0.005% (gnomAD) | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant negative effects.
View complete mutation data：
Gene Ontology (GO)
| • RNA methyltransferase activity | • tRNA binding |
| • mRNA methylation | • nucleus |
| • cytoplasm |
Pathways
• m6A RNA methylation
• tRNA processing
Protein Summary
METTL2B is a 442-amino acid protein containing a methyltransferase domain. It localizes to the nucleus and cytoplasm and is involved in post-transcriptional RNA modification. The protein is part of the METTL family that mediates m6A methylation, a key epitranscriptomic mark.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| METTL2B Knockout HEK293 Cell Line | EDJ-KQ14239 | Human | 55798 | Details Get a Quote |
| METTL2B Knockout HeLa Cell Line | EDJ-KQ43009 | Human | 55798 | Details Get a Quote |
| METTL2B Knockout A-549 Cell Line | EDJ-KQ44223 | Human | 55798 | Details Get a Quote |
| METTL2B Knockout HCT 116 Cell Line | EDJ-KQ44224 | Human | 55798 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
