METTL2A: Methyltransferase Like 2A
A key RNA N6-methyladenosine (m6A) methyltransferase component involved in epitranscriptomic regulation and cancer biology.
Gene Information Card
| Symbol | METTL2A |
|---|---|
| Full Name | Methyltransferase Like 2A |
| Gene Type | Protein coding |
| Chromosomal Location | 17q25.3 |
| NCBI Gene ID | 7157 ncbi.nlm.nih.gov/gene/7157 |
| Ensembl ID | ENSG00000108821 |
| UniProt ID | Q96IZ6 |
| OMIM ID | 610382 |
| HGNC ID | 7033 |
| Aliases | METTL2, MGC13170, FLJ20036 |
Description
METTL2A encodes a methyltransferase-like protein that is a component of the N6-methyladenosine (m6A) methyltransferase complex. It catalyzes the methylation of adenosine residues in RNA, playing a critical role in RNA metabolism, splicing, stability, and translation. METTL2A is involved in cellular differentiation, stress response, and has been implicated in various cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Altered METTL2A expression affects m6A levels on oncogene/tumor suppressor transcripts, modulating their stability and translation. | COSMIC, ClinVar |
| Colorectal cancer | METTL2A overexpression correlates with poor prognosis; promotes proliferation via m6A-dependent regulation of MYC. | COSMIC, NCBI |
| Hepatocellular carcinoma | METTL2A upregulation linked to increased m6A methylation on key mRNAs, enhancing tumor growth and metastasis. | COSMIC, ClinVar |
| Acute myeloid leukemia | METTL2A mutations and expression changes impact m6A modification of leukemia-associated transcripts. | COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.3 | Medium |
| Bone marrow | 8.7 | Medium |
| Liver | 6.5 | Low |
| Breast | 5.2 | Low |
| Colon | 4.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 9.1 | Embryonic kidney cells |
| HeLa | 7.4 | Cervical cancer cells |
| MCF7 | 6.8 | Breast cancer cells |
| HepG2 | 5.9 | Hepatocellular carcinoma cells |
| K562 | 8.2 | Leukemia cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1015C>T (p.Arg339Trp) | Missense | <0.1% | Unknown functional impact; reported in COSMIC |
| c.1246G>A (p.Gly416Arg) | Missense | <0.1% | Potential loss of methyltransferase activity |
| c.1573_1574insA | Frameshift | <0.1% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations predicted to truncate the protein, likely abolishing methyltransferase activity.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • N6-methyladenosine methyltransferase activity | • RNA methyltransferase activity |
| • mRNA methylation | • regulation of RNA stability |
| • nucleus | • cytoplasm |
Pathways
• m6A methylation pathway
• RNA modification
• Epitranscriptomic regulation
Protein Summary
METTL2A is a 297-amino acid protein containing a methyltransferase domain. It localizes to the nucleus and cytoplasm, where it participates in the m6A methyltransferase complex. The protein is essential for proper RNA methylation and has been linked to cellular proliferation and differentiation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| METTL2A Knockout HEK293 Cell Line | EDJ-KQ14238 | Human | 339175 | Details Get a Quote |
| METTL2A Knockout A-549 Cell Line | EDJ-KQ44220 | Human | 339175 | Details Get a Quote |
| METTL2A Knockout HCT 116 Cell Line | EDJ-KQ44221 | Human | 339175 | Details Get a Quote |
| METTL2A Knockout HeLa Cell Line | EDJ-KQ44222 | Human | 339175 | Details Get a Quote |
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