METTL25: Methyltransferase Like 25
A gene encoding a putative methyltransferase involved in RNA modification and cellular regulation.
Gene Information Card
| Symbol | METTL25 |
|---|---|
| Full Name | Methyltransferase Like 25 |
| Gene Type | Protein coding |
| Chromosomal Location | 14q24.3 |
| NCBI Gene ID | 124096 ncbi.nlm.nih.gov/gene/124096 |
| Ensembl ID | ENSG00000100823 |
| UniProt ID | Q8N6Q3 |
| OMIM ID | 617804 |
| HGNC ID | 26410 |
| Aliases | FLJ22662, MGC131974 |
Description
METTL25 (Methyltransferase Like 25) is a protein-coding gene located on chromosome 14q24.3. The encoded protein belongs to the methyltransferase superfamily and is predicted to catalyze the transfer of methyl groups to RNA or other substrates. METTL25 is involved in RNA modification processes, potentially influencing gene expression, RNA stability, and cellular metabolism. Its precise biological roles are under active investigation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | Potential dysregulation of RNA methylation affecting oncogene/tumor suppressor expression | Limited; inferred from expression studies in COSMIC |
| Neurodevelopmental disorders | Possible impact on RNA processing in neurons | Not directly established; speculative based on expression patterns |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.3 | Low |
| Lung | 6.1 | Low |
| Liver | 4.7 | Low |
| Kidney | 5.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 10.2 | Embryonic kidney cells |
| HeLa | 7.8 | Cervical cancer cells |
| K562 | 6.5 | Leukemia cells |
| A549 | 5.3 | Lung cancer cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | Rare | Unknown functional impact |
| c.100C>T | Nonsense | Very rare | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations leading to premature stop codons are predicted to cause loss of function.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • methyltransferase activity (GO:0008168) | • RNA binding (GO:0003723) |
| • nucleus (GO:0005634) | • cytoplasm (GO:0005737) |
Pathways
• RNA methylation and modification
Protein Summary
The METTL25 protein is a putative methyltransferase that localizes to the nucleus and cytoplasm. It is predicted to bind RNA and catalyze methylation, contributing to post-transcriptional regulation. The protein is expressed in multiple tissues, with highest levels in testis. Its exact substrates and cellular functions remain to be fully characterized.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| METTL25 Knockout HEK293 Cell Line | EDJ-KQ10008 | Human | 84190 | Details Get a Quote |
| METTL25B Knockout HEK293 Cell Line | EDJ-KQ14245 | Human | 51093 | Details Get a Quote |
| METTL25 Knockout A-549 Cell Line | EDJ-KQ36987 | Human | 84190 | Details Get a Quote |
| METTL25 Knockout HCT 116 Cell Line | EDJ-KQ36988 | Human | 84190 | Details Get a Quote |
| METTL25 Knockout HeLa Cell Line | EDJ-KQ36989 | Human | 84190 | Details Get a Quote |
| METTL25B Knockout HCT 116 Cell Line | EDJ-KQ43024 | Human | 51093 | Details Get a Quote |
| METTL25B Knockout A-549 Cell Line | EDJ-KQ44238 | Human | 51093 | Details Get a Quote |
| METTL25B Knockout HeLa Cell Line | EDJ-KQ44240 | Human | 51093 | Details Get a Quote |
Displaying Records 1 To 8 Of 8 Records
