METTL22
Methyltransferase Like 22
Gene Information Card
| Symbol | METTL22 |
|---|---|
| Full Name | Methyltransferase Like 22 |
| Gene Type | Protein coding |
| Chromosomal Location | 16p13.3 |
| NCBI Gene ID | 79091 ncbi.nlm.nih.gov/gene/79091 |
| Ensembl ID | ENSG00000140987 |
| UniProt ID | Q8N3J3 |
| OMIM ID | 617804 |
| HGNC ID | 28376 |
| Aliases | FLJ22604, MGC131930 |
Description
METTL22 (Methyltransferase Like 22) is a protein-coding gene located on chromosome 16p13.3. It encodes a methyltransferase-like protein involved in methylation processes. The gene is broadly expressed in various tissues and is implicated in cellular functions including RNA modification and protein methylation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | Altered METTL22 expression may affect methylation-dependent signaling pathways | COSMIC, literature |
| Neurodevelopmental disorders | Potential role via methylation of RNA or proteins | ClinVar, OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.2 | Low |
| Liver | 6.1 | Low |
| Kidney | 5.4 | Low |
| Heart | 4.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 10.3 | Moderate expression |
| HeLa | 7.8 | Low expression |
| K562 | 6.5 | Low expression |
| A549 | 5.9 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.01% | Unknown |
| c.100C>T | Nonsense | <0.01% | Likely loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations may lead to truncated protein and loss of methyltransferase activity.
Gain of Function (GOF)
No evidence of gain-of-function mutations reported.
Dominant Negative (DN)
No evidence of dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • methyltransferase activity | • RNA binding |
| • methylation | • nucleus |
| • cytoplasm |
Pathways
• Methylation pathways
• RNA processing
Protein Summary
METTL22 encodes a methyltransferase-like protein of unknown specific substrate. It is predicted to localize to the nucleus and cytoplasm and may participate in methylation of RNA or proteins. Expression is highest in testis and moderate in brain and other tissues.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| METTL22 Knockout HEK293 Cell Line | EDJ-KQ14243 | Human | 79091 | Details Get a Quote |
| METTL22 Knockout A-549 Cell Line | EDJ-KQ44235 | Human | 79091 | Details Get a Quote |
| METTL22 Knockout HCT 116 Cell Line | EDJ-KQ44236 | Human | 79091 | Details Get a Quote |
| METTL22 Knockout HeLa Cell Line | EDJ-KQ44237 | Human | 79091 | Details Get a Quote |
