MED24
Mediator Complex Subunit 24
Gene Information Card
| Symbol | MED24 |
|---|---|
| Full Name | Mediator Complex Subunit 24 |
| Gene Type | protein-coding |
| Chromosomal Location | 17q21.1 |
| NCBI Gene ID | 9862 ncbi.nlm.nih.gov/gene/9862 |
| Ensembl ID | ENSG00000108821 |
| UniProt ID | O75448 |
| OMIM ID | 602282 |
| HGNC ID | 22963 |
| Aliases | TRAP100, DRIP100, ARC100, CRSP100, THRAP4 |
Description
MED24 is a component of the Mediator complex, a multiprotein complex that acts as a bridge between transcription factors and RNA polymerase II. It is essential for regulated transcription of nearly all RNA polymerase II-dependent genes. MED24 specifically interacts with nuclear receptors and other transcription activators to facilitate gene expression.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | MED24 overexpression may contribute to tumorigenesis via enhanced transcriptional coactivation of oncogenic pathways. | PMID: 14562041 |
| Prostate cancer | MED24 is part of the Mediator complex that interacts with androgen receptor, potentially influencing prostate cancer progression. | PMID: 12493763 |
| Colorectal cancer | Altered MED24 expression has been observed in colorectal cancer tissues, suggesting a role in tumor development. | PMID: 19029980 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Thyroid | 10.2 | Medium |
| Adrenal gland | 9.8 | Medium |
| Lymph node | 8.5 | Medium |
| Brain | 6.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 15.0 | Embryonic kidney cells |
| HeLa | 12.5 | Cervical cancer cells |
| MCF7 | 11.0 | Breast cancer cells |
| HepG2 | 9.8 | Liver cancer cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T | Missense | <0.01% | Unknown |
| c.567_568insA | Frameshift | <0.01% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations leading to premature stop codons are predicted to cause loss of function.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • transcription coactivator activity (GO:0003712) | • nucleoplasm (GO:0005654) |
| • mediator complex (GO:0016592) | • regulation of transcription by RNA polymerase II (GO:0006357) |
Pathways
• Mediator complex (Reactome: R-HSA-212436)
• Transcriptional regulation by TP53 (Reactome: R-HSA-3700989)
Protein Summary
MED24 is a 100 kDa protein that contains a conserved Med24 domain. It localizes to the nucleus and is a stable component of the Mediator complex. The protein interacts with various transcription factors, including nuclear receptors, and is required for proper transcriptional activation. Its expression is ubiquitous but varies across tissues.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MED24 Knockout HEK293 Cell Line | EDJ-KQ6789 | Human | 9862 | Details Get a Quote |
| MED24 Knockout A-549 Cell Line | EDJ-KQ31264 | Human | 9862 | Details Get a Quote |
| MED24 Knockout HCT 116 Cell Line | EDJ-KQ31265 | Human | 9862 | Details Get a Quote |
| MED24 Knockout HeLa Cell Line | EDJ-KQ31266 | Human | 9862 | Details Get a Quote |
