MED21: Mediator Complex Subunit 21
A core component of the Mediator complex involved in transcriptional regulation
Gene Information Card
| Symbol | MED21 |
|---|---|
| Full Name | Mediator Complex Subunit 21 |
| Gene Type | Protein coding |
| Chromosomal Location | 12p11.23 |
| NCBI Gene ID | 9412 ncbi.nlm.nih.gov/gene/9412 |
| Ensembl ID | ENSG00000111247 |
| UniProt ID | Q9H7Z6 |
| OMIM ID | 605044 |
| HGNC ID | 16833 |
| Aliases | SURB7, TRAP21, SRB7 |
Description
MED21 encodes a component of the Mediator complex, a multiprotein coactivator required for RNA polymerase II transcription. The protein directly interacts with other Mediator subunits and transcription factors to regulate gene expression. MED21 is evolutionarily conserved and essential for embryonic development.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | Dysregulation of Mediator complex alters transcription of oncogenes/tumor suppressors | PMID: 22939622 |
| Developmental disorders | MED21 mutations may impair Mediator function leading to transcriptional dysregulation | Inferred from Mediator complex studies |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.2 | Low |
| Heart | 6.1 | Low |
| Liver | 5.3 | Low |
| Kidney | 4.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 10.1 | Moderate expression |
| HeLa | 8.7 | Moderate expression |
| K562 | 7.3 | Low expression |
| HepG2 | 6.8 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.01% | Unknown functional impact |
| c.100C>T | Synonymous | <0.01% | No predicted effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • transcription coactivator activity (GO:0003712) | • regulation of transcription by RNA polymerase II (GO:0006357) |
| • mediator complex (GO:0016592) | • nucleus (GO:0005634) |
Pathways
• Mediator complex (Reactome: R-HSA-212436)
• RNA polymerase II transcription (Reactome: R-HSA-73857)
Protein Summary
MED21 is a 144-amino acid protein (16.5 kDa) that contains a conserved SRB7 domain. It directly binds MED4 and MED31 within the Mediator complex. The protein is ubiquitously expressed and localizes to the nucleus. Its structure includes a helical domain critical for complex assembly.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MED21 Knockout HEK293 Cell Line | EDJ-KQ50869 | Human | 9412 | Details Get a Quote |
| MED21 Knockout HeLa Cell Line | EDJ-KQ55157 | Human | 9412 | Details Get a Quote |
| MED21 Knockout A-549 Cell Line | EDJ-KQ63637 | Human | 9412 | Details Get a Quote |
| MED21 Knockout HCT 116 Cell Line | EDJ-KQ72099 | Human | 9412 | Details Get a Quote |
