ME3 (Malic Enzyme 3)
Mitochondrial NADP(+)-dependent malic enzyme gene
Gene Information Card
| Symbol | ME3 |
|---|---|
| Full Name | Malic Enzyme 3 |
| Gene Type | protein-coding |
| Chromosomal Location | 11q14.1 |
| NCBI Gene ID | 10873 ncbi.nlm.nih.gov/gene/10873 |
| Ensembl ID | ENSG00000151366 |
| UniProt ID | Q16798 |
| OMIM ID | 604626 |
| HGNC ID | 6985 |
| Aliases | NADP-ME, MGC126806, MGC126807 |
Description
ME3 encodes a mitochondrial NADP(+)-dependent malic enzyme that catalyzes the oxidative decarboxylation of malate to pyruvate, producing NADPH. This enzyme plays a key role in cellular metabolism, including lipogenesis, redox balance, and the tricarboxylic acid (TCA) cycle. ME3 is implicated in cancer metabolism and other metabolic disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Altered NADPH production may support anabolic processes and redox balance in tumor cells. | COSMIC; literature |
| Metabolic syndrome | Dysregulation of malic enzyme activity can affect lipid metabolism and insulin sensitivity. | OMIM; literature |
| Neurodegenerative disorders | Mitochondrial dysfunction and oxidative stress linked to ME3 activity changes. | UniProt; literature |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Adipose tissue | 8.3 | Low |
| Brain | 6.1 | Low |
| Heart | 4.2 | Low |
| Skeletal muscle | 3.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 15.2 | Hepatocellular carcinoma cell line |
| MCF7 | 9.7 | Breast cancer cell line |
| A549 | 7.4 | Lung carcinoma cell line |
| HEK293 | 5.1 | Embryonic kidney cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234G>A (p.Gly412Arg) | Missense | <0.1% | Unknown; predicted possibly damaging |
| c.567C>T (p.Pro189Leu) | Missense | <0.1% | Unknown; predicted benign |
| c.890A>G (p.Asn297Ser) | Missense | <0.1% | Unknown; predicted tolerated |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence of dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Pyruvate metabolism (Reactome: R-HSA-70268)
• Metabolism of carbohydrates (Reactome: R-HSA-71387)
• TCA cycle and respiratory electron transport (Reactome: R-HSA-1428517)
Protein Summary
ME3 is a mitochondrial NADP(+)-dependent malic enzyme that converts malate to pyruvate, generating NADPH. It is a homotetramer and plays a role in lipogenesis, redox homeostasis, and the TCA cycle. The protein is expressed in various tissues, with highest levels in liver and adipose tissue. Mutations in ME3 are rare and of uncertain significance.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ME3 Knockout HEK293 Cell Line | EDJ-KQ7196 | Human | 10873 | Details Get a Quote |
| PSME3IP1 Knockout HEK293 Cell Line | EDJ-KQ9425 | Human | 80011 | Details Get a Quote |
| ME3 Knockout A-549 Cell Line | EDJ-KQ32136 | Human | 10873 | Details Get a Quote |
| ME3 Knockout HeLa Cell Line | EDJ-KQ32137 | Human | 10873 | Details Get a Quote |
| PSME3IP1 Knockout A-549 Cell Line | EDJ-KQ36081 | Human | 80011 | Details Get a Quote |
| PSME3IP1 Knockout HCT 116 Cell Line | EDJ-KQ36082 | Human | 80011 | Details Get a Quote |
| PSME3IP1 Knockout HeLa Cell Line | EDJ-KQ34836 | Human | 80011 | Details Get a Quote |
| NME3 Knockout HEK293 Cell Line | EDJ-KQ50483 | Human | 4832 | Details Get a Quote |
| PSME3 Knockout HEK293 Cell Line | EDJ-KQ50941 | Human | 10197 | Details Get a Quote |
| NME3 Knockout HeLa Cell Line | EDJ-KQ54001 | Human | 4832 | Details Get a Quote |
| PSME3 Knockout HeLa Cell Line | EDJ-KQ55342 | Human | 10197 | Details Get a Quote |
| NME3 Knockout A-549 Cell Line | EDJ-KQ62494 | Human | 4832 | Details Get a Quote |
| PSME3 Knockout A-549 Cell Line | EDJ-KQ63822 | Human | 10197 | Details Get a Quote |
| NME3 Knockout HCT 116 Cell Line | EDJ-KQ70960 | Human | 4832 | Details Get a Quote |
| PSME3 Knockout HCT 116 Cell Line | EDJ-KQ72284 | Human | 10197 | Details Get a Quote |
Displaying Records 1 To 15 Of 16 Records
