MDP1: Magnesium-Dependent Phosphatase 1
A gene encoding a magnesium-dependent phosphatase involved in cellular metabolism and signaling.
Gene Information Card
| Symbol | MDP1 |
|---|---|
| Full Name | Magnesium-Dependent Phosphatase 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 14q32.33 |
| NCBI Gene ID | 145553 ncbi.nlm.nih.gov/gene/145553 |
| Ensembl ID | ENSG00000100823 |
| UniProt ID | Q9NQZ2 |
| OMIM ID | 610528 |
| HGNC ID | 28767 |
| Aliases | DUSP28, FLJ22624 |
Description
MDP1 encodes a magnesium-dependent phosphatase that belongs to the dual-specificity phosphatase (DUSP) family. The enzyme catalyzes the dephosphorylation of phosphoserine, phosphothreonine, and phosphotyrosine residues, playing a role in cellular signaling and metabolic processes. It is widely expressed and may be involved in cancer and other diseases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | Altered expression may affect MAPK/ERK signaling pathways | COSMIC; literature |
| Prostate cancer | Overexpression linked to tumor progression | COSMIC; literature |
| Breast cancer | Differential expression observed | COSMIC; literature |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.3 | Low |
| Liver | 6.1 | Low |
| Kidney | 5.4 | Low |
| Heart | 4.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 10.1 | Moderate expression |
| HeLa | 7.8 | Low expression |
| MCF7 | 6.5 | Low expression |
| A549 | 5.9 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.1% | Unknown |
| c.100C>T | Missense | <0.1% | Unknown |
| c.200G>A | Missense | <0.1% | Unknown |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• MAPK signaling pathway
• Dual-specificity phosphatase regulation
Protein Summary
MDP1 is a 184-amino acid protein with a molecular weight of approximately 21 kDa. It contains a dual-specificity phosphatase domain that requires magnesium ions for activity. The protein is localized in the cytoplasm and nucleus, and its expression is regulated in a tissue-specific manner. Structural studies reveal a conserved active site with a P-loop motif (HCXXGXXR) essential for catalysis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MDP1 Knockout HEK293 Cell Line | EDJ-KQ10447 | Human | 145553 | Details Get a Quote |
| MDP1 Knockout HeLa Cell Line | EDJ-KQ36543 | Human | 145553 | Details Get a Quote |
| MDP1 Knockout A-549 Cell Line | EDJ-KQ37829 | Human | 145553 | Details Get a Quote |
| MDP1 Knockout HCT 116 Cell Line | EDJ-KQ37830 | Human | 145553 | Details Get a Quote |
| NEDD8-MDP1 Knockout HEK293 Cell Line | EDJ-KQ52490 | Human | 100528064 | Details Get a Quote |
| NEDD8-MDP1 Knockout HeLa Cell Line | EDJ-KQ60953 | Human | 100528064 | Details Get a Quote |
| NEDD8-MDP1 Knockout A-549 Cell Line | EDJ-KQ69428 | Human | 100528064 | Details Get a Quote |
| NEDD8-MDP1 Knockout HCT 116 Cell Line | EDJ-KQ77779 | Human | 100528064 | Details Get a Quote |
