MCTS2 (MCTS2, MCTS2P, MCTS2 Pseudogene)
Pseudogene of the MCTS1 family, potentially involved in translational regulation and cancer biology
Gene Information Card
| Symbol | MCTS2 |
|---|---|
| Full Name | MCTS2, MCTS1 pseudogene 2 |
| Gene Type | Pseudogene |
| Chromosomal Location | 15q23 |
| NCBI Gene ID | 100129924 ncbi.nlm.nih.gov/gene/100129924 |
| Ensembl ID | ENSG00000204176 |
| UniProt ID | Not applicable (pseudogene) |
| OMIM ID | Not available |
| HGNC ID | HGNC:49576 |
| Aliases | MCTS2P, MCTS1P2 |
Description
MCTS2 (MCTS1 pseudogene 2) is a processed pseudogene derived from the MCTS1 gene, which encodes a protein involved in translational initiation and cell cycle progression. Located on chromosome 15q23, MCTS2 lacks an open reading frame and is not translated into a functional protein. However, pseudogenes like MCTS2 can regulate their parent gene expression through mechanisms such as microRNA sponging or generation of small RNAs. MCTS2 expression has been detected in various tissues and may be dysregulated in cancer.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | Potential dysregulation of MCTS1 pathway via pseudogene-mediated regulation | Limited evidence; expression changes observed in tumor samples |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 0.3 | Low |
| Brain | 0.1 | Low |
| Lung | 0.2 | Low |
| Breast | 0.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 0.2 | Low expression |
| MCF7 | 0.1 | Low expression |
| A549 | 0.3 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No known pathogenic variants | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
Not applicable (pseudogene)
Gain of Function (GOF)
Not applicable (pseudogene)
Dominant Negative (DN)
Not applicable (pseudogene)
View complete mutation data：
Protein Summary
MCTS2 is a pseudogene and does not encode a protein. It is derived from the MCTS1 gene, which encodes a protein involved in translation initiation and cell cycle control.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MCTS2 Knockout HEK293 Cell Line | EDJ-KQ14222 | Human | 100101490 | Details Get a Quote |
| MCTS2 Knockout A-549 Cell Line | EDJ-KQ42969 | Human | 100101490 | Details Get a Quote |
| MCTS2 Knockout HCT 116 Cell Line | EDJ-KQ44184 | Human | 100101490 | Details Get a Quote |
| MCTS2 Knockout HeLa Cell Line | EDJ-KQ44185 | Human | 100101490 | Details Get a Quote |
