MCRIP1
MAPK Regulated Corepressor Interacting Protein 1
Gene Information Card
| Symbol | MCRIP1 |
|---|---|
| Full Name | MAPK Regulated Corepressor Interacting Protein 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 7p21.3 |
| NCBI Gene ID | 25909 ncbi.nlm.nih.gov/gene/25909 |
| Ensembl ID | ENSG00000105976 |
| UniProt ID | Q8N5J2 |
| OMIM ID | 617564 |
| HGNC ID | 25138 |
| Aliases | FAM195B, C7orf36 |
Description
MCRIP1 (MAPK Regulated Corepressor Interacting Protein 1) is a protein-coding gene located on chromosome 7p21.3. It encodes a protein that interacts with the MAPK signaling pathway and functions as a transcriptional corepressor. MCRIP1 is involved in regulating gene expression and has been implicated in various cellular processes including cell proliferation and differentiation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | Altered expression may affect MAPK signaling and transcriptional regulation | Limited evidence from expression studies |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 15.2 | Medium |
| Brain | 8.5 | Low |
| Lung | 6.1 | Low |
| Liver | 4.3 | Low |
| Kidney | 3.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 12.0 | Moderate expression |
| HeLa | 8.5 | Low expression |
| A549 | 6.2 | Low expression |
| MCF7 | 5.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.200C>T | Missense | <0.1% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
Not established
Gain of Function (GOF)
Not established
Dominant Negative (DN)
Not established
View complete mutation data：
Gene Ontology (GO)
| • transcription corepressor activity | • protein binding |
| • nucleus |
Pathways
• MAPK signaling pathway
Protein Summary
MCRIP1 encodes a 244-amino acid protein that localizes to the nucleus and acts as a transcriptional corepressor. It interacts with components of the MAPK signaling cascade, modulating downstream gene expression. The protein contains a conserved domain of unknown function (DUF) and is expressed in multiple tissues with highest levels in testis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MCRIP1 Knockout HEK293 Cell Line | EDJ-KQ2812 | Human | 348262 | Details Get a Quote |
| MCRIP1 Knockout A-549 Cell Line | EDJ-KQ22398 | Human | 348262 | Details Get a Quote |
| MCRIP1 Knockout HCT 116 Cell Line | EDJ-KQ23767 | Human | 348262 | Details Get a Quote |
| MCRIP1 Knockout HeLa Cell Line | EDJ-KQ23768 | Human | 348262 | Details Get a Quote |
